Giant Cell Arteritis: 2018 Review

Overview

Journal Mo Med

Specialty General Medicine

Date 2018 Nov 3

PMID 30385998

Citations 21

Authors

Anne Winkler

David True

Affiliations

Soon will be listed here.

Abstract

Giant cell arteritis is the most common large vessel vasculitis. Classic symptoms include headaches, scalp tenderness, visual loss and muscle stiffness and pain. First line treatment is with high dose steroids but methotrexate may be of some help in decreasing steroid use. Tocilizumab has been shown to significantly decrease relapse rate and lower steroid cumulative dose.

Citing Articles

Cardiology-Rheumatology Intersections in Aortitis and Aortic Aneurysms: Focus on Early Recognition and Management.

Macrinici V, Nso N, Cochran M, Mehreen A, Tsourdinis G, Ikram M JACC Case Rep. 2024; 29(23):102818.

PMID: 39691318 PMC: 11646920. DOI: 10.1016/j.jaccas.2024.102818.

Association of clinical, imaging and laboratory parameters with adverse effects of glucocorticoid therapy in patients with giant cell arteritis.

Schweiger L, Hafner F, Meinitzer A, Brodmann M, Dejaco C, Jud P Front Med (Lausanne). 2024; 11:1382946.

PMID: 38841591 PMC: 11150613. DOI: 10.3389/fmed.2024.1382946.

A Case of Large Vessel Giant Cell Arteritis Presenting With Cough and Diagnosed Using an FDG-PET Scan.

Danial Azmy Habib S, Gunawardena M Cureus. 2024; 16(5):e59686.

PMID: 38836133 PMC: 11150049. DOI: 10.7759/cureus.59686.

Oxidative stress in the eye and its role in the pathophysiology of ocular diseases.

Bohm E, Buonfiglio F, Voigt A, Bachmann P, Safi T, Pfeiffer N Redox Biol. 2023; 68:102967.

PMID: 38006824 PMC: 10701459. DOI: 10.1016/j.redox.2023.102967.

Giant cell arteritis with severe intracranial involvement diagnosed and treated early.

Mineji K, Yako R, Toki N, Tomobuchi M, Nakao N Surg Neurol Int. 2023; 14:332.

PMID: 37810294 PMC: 10559434. DOI: 10.25259/SNI_529_2023.

References

Pamuk O, Donmez S, Karahan B, Pamuk G, Cakir N . Giant cell arteritis and polymyalgia rheumatica in northwestern Turkey: Clinical features and epidemiological data. Clin Exp Rheumatol. 2009; 27(5):830-3. View

Carmona F, Gonzalez-Gay M, Martin J . Genetic component of giant cell arteritis. Rheumatology (Oxford). 2013; 53(1):6-18. DOI: 10.1093/rheumatology/ket231. View

Nuenninghoff D, Hunder G, Christianson T, McClelland R, Matteson E . Incidence and predictors of large-artery complication (aortic aneurysm, aortic dissection, and/or large-artery stenosis) in patients with giant cell arteritis: a population-based study over 50 years. Arthritis Rheum. 2003; 48(12):3522-31. DOI: 10.1002/art.11353. View

Smetana G, Shmerling R . Does this patient have temporal arteritis?. JAMA. 2002; 287(1):92-101. DOI: 10.1001/jama.287.1.92. View

. 2015 ACR/ARHP Annual Meeting Abstract Supplement. Arthritis Rheumatol. 2015; 67 Suppl 10:1-4046. DOI: 10.1002/art.39448. View

Conway R, ONeill L, OFlynn E, Gallagher P, McCarthy G, Murphy C . Ustekinumab for the treatment of refractory giant cell arteritis. Ann Rheum Dis. 2016; 75(8):1578-9. DOI: 10.1136/annrheumdis-2016-209351. View

Carmona F, Martin J, Gonzalez-Gay M . New insights into the pathogenesis of giant cell arteritis and hopes for the clinic. Expert Rev Clin Immunol. 2015; 12(1):57-66. DOI: 10.1586/1744666X.2016.1089173. View

Borchers A, Gershwin M . Giant cell arteritis: a review of classification, pathophysiology, geoepidemiology and treatment. Autoimmun Rev. 2012; 11(6-7):A544-54. DOI: 10.1016/j.autrev.2012.01.003. View

Ninan J, Lester S, Hill C . Giant cell arteritis. Best Pract Res Clin Rheumatol. 2016; 30(1):169-88. DOI: 10.1016/j.berh.2016.05.001. View

10.

Gonzalez-Gay M, Vazquez-Rodriguez T, Lopez-Diaz M, Miranda-Filloy J, Gonzalez-Juanatey C, Martin J . Epidemiology of giant cell arteritis and polymyalgia rheumatica. Arthritis Rheum. 2009; 61(10):1454-61. DOI: 10.1002/art.24459. View

11.

Spiera R, Mitnick H, Kupersmith M, Richmond M, Spiera H, Peterson M . A prospective, double-blind, randomized, placebo controlled trial of methotrexate in the treatment of giant cell arteritis (GCA). Clin Exp Rheumatol. 2001; 19(5):495-501. View

12.

Hoffman G, Cid M, Rendt-Zagar K, Merkel P, Weyand C, Stone J . Infliximab for maintenance of glucocorticosteroid-induced remission of giant cell arteritis: a randomized trial. Ann Intern Med. 2007; 146(9):621-30. DOI: 10.7326/0003-4819-146-9-200705010-00004. View

13.

Carmona F, Mackie S, Martin J, Taylor J, Vaglio A, Eyre S . A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility. Am J Hum Genet. 2015; 96(4):565-80. PMC: 4385191. DOI: 10.1016/j.ajhg.2015.02.009. View

14.

Stone J, Tuckwell K, Dimonaco S, Klearman M, Aringer M, Blockmans D . Trial of Tocilizumab in Giant-Cell Arteritis. N Engl J Med. 2017; 377(4):317-328. DOI: 10.1056/NEJMoa1613849. View

15.

Gonzalez-Gay M, Garcia-Porrua C, Llorca J, Hajeer A, Branas F, Dababneh A . Visual manifestations of giant cell arteritis. Trends and clinical spectrum in 161 patients. Medicine (Baltimore). 2000; 79(5):283-92. DOI: 10.1097/00005792-200009000-00001. View

16.

Jover J, Hernandez-Garcia C, Morado I, Vargas E, Banares A, Fernandez-Gutierrez B . Combined treatment of giant-cell arteritis with methotrexate and prednisone. a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2001; 134(2):106-14. DOI: 10.7326/0003-4819-134-2-200101160-00010. View

17.

Lie J . Aortic and extracranial large vessel giant cell arteritis: a review of 72 cases with histopathologic documentation. Semin Arthritis Rheum. 1995; 24(6):422-31. DOI: 10.1016/s0049-0172(95)80010-7. View

18.

Martinez-Taboada V, Rodriguez-Valverde V, Carreno L, Lopez-Longo J, Figueroa M, Belzunegui J . A double-blind placebo controlled trial of etanercept in patients with giant cell arteritis and corticosteroid side effects. Ann Rheum Dis. 2007; 67(5):625-30. DOI: 10.1136/ard.2007.082115. View

19.

Seror R, Baron G, Hachulla E, Debandt M, Larroche C, Puechal X . Adalimumab for steroid sparing in patients with giant-cell arteritis: results of a multicentre randomised controlled trial. Ann Rheum Dis. 2013; 73(12):2074-81. DOI: 10.1136/annrheumdis-2013-203586. View