Deciphering Molecular Properties of Hypermutated Gastrointestinal Cancer

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2018 Nov 2

PMID 30381870

Citations 8

Authors

Wangxiong Hu

Yanmei Yang

Weiting Ge

Shu Zheng

Affiliations

Soon will be listed here.

Abstract

Great mutational heterogeneity is observed both across cancer types (>1000-fold) and within a given cancer type, with a fraction harboring >10 mutations per million bases, thus termed hypermutation. We determined the genome-wide effects of high mutation load on the transcriptome and methylome of two cancer types; namely, colorectal cancer (CRC) and stomach adenocarcinoma (STAD). Briefly, hierarchical clustering of the expression and methylation profiles showed that the majority of CRC and STAD hypermutated samples were mixed and separated from their respective non-hypermutated samples, exceeding the boundary of tissue specificity. Further in-detailed exploration uncovered that the underlying molecular mechanism may be related to the perturbation of chromatin remodeling genes.

Citing Articles

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An exploration of gastric cancer with heterogeneous mismatch repair status.

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