The Relationship Between the Effect of Matured Hop Extract and Physical Activity on Reducing Body Fat: Re-analysis of Data from a Randomized, Double-blind, Placebo-controlled Parallel Group Study

Overview

Journal Nutr J

Publisher Biomed Central

Specialty Nutritional Sciences

Date 2018 Nov 1

PMID 30376838

Citations 3

Authors

Shigeo Suzuki

Takahiro Yamazaki

Chika Takahashi

Yuji Kaneko

Yumie Morimoto-Kobayashi

Mikio Katayama

Affiliations

Soon will be listed here.

Abstract

Background: We recently reported that successive ingestion of matured hop extract (MHE), produced by oxidation of hops, results in a reduction of body fat in healthy overweight participants. A combined effect of MHE and physical activity on body fat has not been investigated. Thus, we re-analyzed data from the previous study to explore the relationship between the effect of MHE and walking as an index of physical activity.

Methods: This analysis uses existing data from a randomized, double-blind, placebo-controlled parallel group study in which MHE (active) or placebo was given for 12 w to 200 healthy overweight Japanese, from May to December 2014. Correlation between the change in abdominal fat areas at 12 w and the number of steps taken per day was tested by Spearman's correlation coefficient test. The subjects were stratified using the average number of steps per day of Japanese into walking less and walking more subgroups (WL and WM, respectively) as follows: placebo (WL, n = 43; WM, n = 44) and active (WL, n = 49; WM, n = 42). Reductions in total, visceral, and subcutaneous fat area (TFA, VFA and SFA, respectively) were evaluated. The interaction effect between ingestion (active/placebo) and walking (WL/WM) was analyzed using two-way analysis of variance (ANOVA).

Results: There was a significant negative correlation between the change in VFA and daily steps taken in the active group (r = - 0.208, P = 0.048). No significant correlation in TFA or SFA. Although the interaction effect in TFA was not significant, the main effect of ingestion was significant (P = 0.045). In contrast, the interaction effect in VFA was suggested to be synergistic (P = 0.055).

Conclusion: The results suggested that MHE ingestion combined with light intensity exercise would induce a greater reduction in VFA which would be beneficial for obese or overweight individuals in reducing obesity and obesity-related diseases.

Trial Registration: UMIN-CTR UMIN000014185 registered 6 June 2014.

Citing Articles

Connectedness to Nature Does Not Explain the Variation in Physical Activity and Body Composition in Adults and Older People.

Teixeira A, Gabriel R, Martinho J, Pinto G, Quaresma L, Faria A Int J Environ Res Public Health. 2021; 18(22).

PMID: 34831707 PMC: 8619523. DOI: 10.3390/ijerph182211951.

Cinnamon and Hop Extracts as Potential Immunomodulators for Severe COVID-19 Cases.

Lucas K, Frohlich-Nowoisky J, Oppitz N, Ackermann M Front Plant Sci. 2021; 12:589783.

PMID: 33719281 PMC: 7952639. DOI: 10.3389/fpls.2021.589783.

Improving Effects of Hop-Derived Bitter Acids in Beer on Cognitive Functions: A New Strategy for Vagus Nerve Stimulation.

Ayabe T, Fukuda T, Ano Y Biomolecules. 2020; 10(1).

PMID: 31940997 PMC: 7022854. DOI: 10.3390/biom10010131.

References

Park H, Lee K . Greater beneficial effects of visceral fat reduction compared with subcutaneous fat reduction on parameters of the metabolic syndrome: a study of weight reduction programmes in subjects with visceral and subcutaneous obesity. Diabet Med. 2005; 22(3):266-72. DOI: 10.1111/j.1464-5491.2004.01395.x. View

Kleist B, Wahrburg U, Stehle P, Schomaker R, Greiwing A, Stoffel-Wagner B . Moderate Walking Enhances the Effects of an Energy-Restricted Diet on Fat Mass Loss and Serum Insulin in Overweight and Obese Adults in a 12-Week Randomized Controlled Trial. J Nutr. 2017; 147(10):1875-1884. DOI: 10.3945/jn.117.251744. View

de Matteis R, Lucertini F, Guescini M, Polidori E, Zeppa S, Stocchi V . Exercise as a new physiological stimulus for brown adipose tissue activity. Nutr Metab Cardiovasc Dis. 2012; 23(6):582-90. DOI: 10.1016/j.numecd.2012.01.013. View

Suzuki S, Morimoto-Kobayashi Y, Takahashi C, Taniguchi Y, Katayama M . Genetic, acute and subchronic toxicity studies of matured hop extract produced by extraction from heat-treated hops. J Toxicol Sci. 2018; 43(7):473-484. DOI: 10.2131/jts.43.473. View

Morimoto-Kobayashi Y, Ohara K, Ashigai H, Kanaya T, Koizumi K, Manabe F . Matured hop extract reduces body fat in healthy overweight humans: a randomized, double-blind, placebo-controlled parallel group study. Nutr J. 2016; 15:25. PMC: 4784395. DOI: 10.1186/s12937-016-0144-2. View

Egras A, Hamilton W, Lenz T, Monaghan M . An evidence-based review of fat modifying supplemental weight loss products. J Obes. 2010; 2011. PMC: 2931392. DOI: 10.1155/2011/297315. View

Narkiewicz K . Obesity and hypertension--the issue is more complex than we thought. Nephrol Dial Transplant. 2005; 21(2):264-7. DOI: 10.1093/ndt/gfi290. View

Smith U . Abdominal obesity: a marker of ectopic fat accumulation. J Clin Invest. 2015; 125(5):1790-2. PMC: 4463217. DOI: 10.1172/JCI81507. View

Marco-Ramell A, Tulipani S, Palau-Rodriguez M, Gonzalez-Dominguez R, Minarro A, Jauregui O . Untargeted Profiling of Concordant/Discordant Phenotypes of High Insulin Resistance and Obesity To Predict the Risk of Developing Diabetes. J Proteome Res. 2018; 17(7):2307-2317. DOI: 10.1021/acs.jproteome.7b00855. View

10.

Yamazaki T, Morimoto-Kobayashi Y, Koizumi K, Takahashi C, Nakajima S, Kitao S . Secretion of a gastrointestinal hormone, cholecystokinin, by hop-derived bitter components activates sympathetic nerves in brown adipose tissue. J Nutr Biochem. 2018; 64:80-87. DOI: 10.1016/j.jnutbio.2018.10.009. View

11.

Kishida K, Funahashi T, Matsuzawa Y, Shimomura I . Visceral adiposity as a target for the management of the metabolic syndrome. Ann Med. 2011; 44(3):233-41. DOI: 10.3109/07853890.2011.564202. View

12.

Nakamura K, Fuster J, Walsh K . Adipokines: a link between obesity and cardiovascular disease. J Cardiol. 2013; 63(4):250-9. PMC: 3989503. DOI: 10.1016/j.jjcc.2013.11.006. View

13.

Lu P, Zhang C, Lifshitz L, Zhuge R . Extraoral bitter taste receptors in health and disease. J Gen Physiol. 2017; 149(2):181-197. PMC: 5299619. DOI: 10.1085/jgp.201611637. View

14.

Thomas D, Bouchard C, Church T, Slentz C, Kraus W, Redman L . Why do individuals not lose more weight from an exercise intervention at a defined dose? An energy balance analysis. Obes Rev. 2012; 13(10):835-47. PMC: 3771367. DOI: 10.1111/j.1467-789X.2012.01012.x. View

15.

Rodgers R, Tschop M, Wilding J . Anti-obesity drugs: past, present and future. Dis Model Mech. 2012; 5(5):621-6. PMC: 3424459. DOI: 10.1242/dmm.009621. View

16.

Morimoto-Kobayashi Y, Ohara K, Takahashi C, Kitao S, Wang G, Taniguchi Y . Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity. PLoS One. 2015; 10(6):e0131042. PMC: 4476742. DOI: 10.1371/journal.pone.0131042. View

17.

Hiuge-Shimizu A, Kishida K, Funahashi T, Ishizaka Y, Oka R, Okada M . Reduction of visceral fat correlates with the decrease in the number of obesity-related cardiovascular risk factors in Japanese with Abdominal Obesity (VACATION-J Study). J Atheroscler Thromb. 2012; 19(11):1006-18. DOI: 10.5551/jat.12963. View

18.

Washburn R, Szabo A, Lambourne K, Willis E, Ptomey L, Honas J . Does the method of weight loss effect long-term changes in weight, body composition or chronic disease risk factors in overweight or obese adults? A systematic review. PLoS One. 2014; 9(10):e109849. PMC: 4198137. DOI: 10.1371/journal.pone.0109849. View

19.

Taniguchi Y, Matsukura Y, Taniguchi H, Koizumi H, Katayama M . Development of preparative and analytical methods of the hop bitter acid oxide fraction and chemical properties of its components. Biosci Biotechnol Biochem. 2015; 79(10):1684-94. DOI: 10.1080/09168451.2015.1042832. View

20.

Steenackers B, De Cooman L, De Vos D . Chemical transformations of characteristic hop secondary metabolites in relation to beer properties and the brewing process: a review. Food Chem. 2014; 172:742-56. DOI: 10.1016/j.foodchem.2014.09.139. View