Emerging Potential of Immediate Early Response Gene X-1 in Cardiovascular and Metabolic Diseases

Overview

Journal J Am Heart Assoc

Specialty Cardiology & Vascular Diseases

Date 2018 Oct 31

PMID 30373431

Citations 3

Authors

Mohd Shahid

Erin L Hermes

David Chandra

Mohammad Tauseef

M Rizwan Siddiqui

M Hafeez Faridi

Mei X Wu

Affiliations

Soon will be listed here.

Citing Articles

Pharmacological modulation of PI3K/PTEN/Akt/mTOR/ERK signaling pathways in ischemic injury: a mechanistic perspective.

Khan H, Singh A, Singh Y, Sharma D, Dua K, Grewal A Metab Brain Dis. 2025; 40(3):131.

PMID: 40009091 DOI: 10.1007/s11011-025-01543-8.

Integrating transcriptomics, eQTL, and Mendelian randomization to dissect monocyte roles in severe COVID-19 and gout flare.

Li J, Yang G, Liu J, Li G, Zhou H, He Y Front Genet. 2024; 15:1385316.

PMID: 39385934 PMC: 11461236. DOI: 10.3389/fgene.2024.1385316.

The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment.

Abcouwer S, Scavuzzi B, Kish P, Kong D, Shanmugam S, Le X J Neuroinflammation. 2024; 21(1):74.

PMID: 38528525 PMC: 10964713. DOI: 10.1186/s12974-024-03062-2.

Emerging Potential of Immediate Early Response Gene X-1 in Cardiovascular and Metabolic Diseases.

Shahid M, Hermes E, Chandra D, Tauseef M, Siddiqui M, Faridi M J Am Heart Assoc. 2018; 7(21):e009261.

PMID: 30373431 PMC: 6404175. DOI: 10.1161/JAHA.118.009261.

References

Ramsey H, Wu M . Mitochondrial anti-oxidant protects IEX-1 deficient mice from organ damage during endotoxemia. Int Immunopharmacol. 2014; 23(2):658-63. PMC: 4394602. DOI: 10.1016/j.intimp.2014.10.019. View

Arlt A, Schafer H . Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis. Eur J Cell Biol. 2010; 90(6-7):545-52. DOI: 10.1016/j.ejcb.2010.10.002. View

Shen J, Chandrasekharan U, Ashraf M, Long E, Morton R, Liu Y . Lack of mitogen-activated protein kinase phosphatase-1 protects ApoE-null mice against atherosclerosis. Circ Res. 2010; 106(5):902-10. PMC: 2847792. DOI: 10.1161/CIRCRESAHA.109.198069. View

Wensveen F, Alves N, Derks I, Reedquist K, Eldering E . Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1. Apoptosis. 2011; 16(7):708-21. PMC: 3098366. DOI: 10.1007/s10495-011-0599-8. View

Prall W, Czibere A, Grall F, Spentzos D, Steidl U, Giagounidis A . Differential gene expression of bone marrow-derived CD34+ cells is associated with survival of patients suffering from myelodysplastic syndrome. Int J Hematol. 2009; 89(2):173-187. DOI: 10.1007/s12185-008-0242-9. View

Shahid M, Hermes E, Chandra D, Tauseef M, Siddiqui M, Faridi M . Emerging Potential of Immediate Early Response Gene X-1 in Cardiovascular and Metabolic Diseases. J Am Heart Assoc. 2018; 7(21):e009261. PMC: 6404175. DOI: 10.1161/JAHA.118.009261. View

Kadenbach B, Arnold S, Lee I, Huttemann M . The possible role of cytochrome c oxidase in stress-induced apoptosis and degenerative diseases. Biochim Biophys Acta. 2004; 1655(1-3):400-8. DOI: 10.1016/j.bbabio.2003.06.005. View

Carew J, Huang P . Mitochondrial defects in cancer. Mol Cancer. 2003; 1:9. PMC: 149412. DOI: 10.1186/1476-4598-1-9. View

Mittal A, Papa S, Franzoso G, Sen R . NF-kappaB-dependent regulation of the timing of activation-induced cell death of T lymphocytes. J Immunol. 2006; 176(4):2183-9. DOI: 10.4049/jimmunol.176.4.2183. View

10.

Nys K, Van Laethem A, Michiels C, Rubio N, Piette J, Garmyn M . A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes. J Invest Dermatol. 2010; 130(9):2269-76. DOI: 10.1038/jid.2010.93. View

11.

Schulze P, De Keulenaer G, Kassik K, Takahashi T, Chen Z, Simon D . Biomechanically induced gene iex-1 inhibits vascular smooth muscle cell proliferation and neointima formation. Circ Res. 2003; 93(12):1210-7. DOI: 10.1161/01.RES.0000103635.38096.2F. View

12.

Arlt A, Kruse M, Breitenbroich M, Gehrz A, Koc B, Minkenberg J . The early response gene IEX-1 attenuates NF-kappaB activation in 293 cells, a possible counter-regulatory process leading to enhanced cell death. Oncogene. 2003; 22(21):3343-51. DOI: 10.1038/sj.onc.1206524. View

13.

Yamashita K, Nakashima S, You F, Hayashi S, Iwama T . Overexpression of immediate early gene X-1 (IEX-1) enhances gamma-radiation-induced apoptosis of human glioma cell line, U87-MG. Neuropathology. 2008; 29(1):20-4. DOI: 10.1111/j.1440-1789.2008.00932.x. View

14.

Wu M, Ao Z, Prasad K, Wu R, Schlossman S . IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival. Science. 1998; 281(5379):998-1001. DOI: 10.1126/science.281.5379.998. View

15.

Nishida M, Maruyama Y, Tanaka R, Kontani K, Nagao T, Kurose H . G alpha(i) and G alpha(o) are target proteins of reactive oxygen species. Nature. 2000; 408(6811):492-5. DOI: 10.1038/35044120. View

16.

Matsuzawa A, Ichijo H . Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid Redox Signal. 2005; 7(3-4):472-81. DOI: 10.1089/ars.2005.7.472. View

17.

Morgan M, Liu Z . Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res. 2010; 21(1):103-15. PMC: 3193400. DOI: 10.1038/cr.2010.178. View

18.

Steensma D, Neiger J, Porcher J, Keats J, Bergsagel P, Dennis T . Rearrangements and amplification of IER3 (IEX-1) represent a novel and recurrent molecular abnormality in myelodysplastic syndromes. Cancer Res. 2009; 69(19):7518-23. PMC: 3157243. DOI: 10.1158/0008-5472.CAN-09-1428. View

19.

Shahid M, Javed A, Chandra D, Ramsey H, Shah D, Khan M . IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity. Sci Rep. 2016; 6:24135. PMC: 4827096. DOI: 10.1038/srep24135. View

20.

Arinze I, Kawai Y . Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements. J Biol Chem. 2005; 280(11):9786-95. DOI: 10.1074/jbc.M414006200. View