ASSOCIATION BETWEEN ACANTHOSIS NIGRICANS AND OTHER CARDIOMETABOLIC RISK FACTORS IN CHILDREN AND ADOLESCENTS WITH OVERWEIGHT AND OBESITY

Overview

Journal Rev Paul Pediatr

Specialty Pediatrics

Date 2018 Oct 27

PMID 30365811

Citations 8

Authors

Heloisa Marcelina da Cunha Palhares

Paula Cunha Zaidan

Fernanda Cristina Mattos Dib

Adriana Paula da Silva

Daniela Cristina Silva Resende

Maria de Fatima Borges

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the presence or absence of acanthosis nigricans and its association with metabolic alterations in a group of obese and overweight children and adolescents.

Methods: A cross sectional study of 161 overweight children and adolescents, who were divided into two groups, according to presence or absence of acanthosis nigricans. Anthropometric measurements (body mass index, skinfolds, abdominal circumference), blood pressure, laboratory tests (fasting glycemia, insulin, lipid profile, triglycerides, uric acid, transaminases) and homeostasis model assessment index.

Results: The acanthosis nigricans group represented 51.5% of the sample. The mean age was similar between groups. The group with acanthosis nigricans presented higher body mass index, Z score of body mass index, body fat percentage, abdominal circumference (p<0.0001), systolic (p=0.006) and diastolic blood pressure (p=0.002). There was no significant difference in the analysis of lipid profile, except for the high-density cholesterol, which was lower (p=0.003) in the group with acanthosis. On the other hand, uric acid (p<0.0001), fasting glycemia (p=0.006), insulin (p<0.0001), glutamic oxalacetic transaminase (p<0.0001), and homeostasis model assessment index (p<0.0001) were significantly higher in the group with acanthosis nigricans.

Conclusions: Acanthosis nigricans in overweight and obese children and adolescents is associated with elevation of body fat, blood pressure, insulin and homeostasis model assessment index, indicating that it is a clinical marker associated with the metabolic syndrome.

Citing Articles

Acanthosis nigricans and its association with cardio-metabolic risk factors in children with overweight/obesity: A school-based cross-sectional study.

Das R, Mangaraj M, Nayak S, Satapathy A, Mahapatro S J Family Med Prim Care. 2025; 14(1):254-258.

PMID: 39989563 PMC: 11844986. DOI: 10.4103/jfmpc.jfmpc_866_24.

Acanthosis nigricans in the pediatric population: a narrative review of the current approach to management in primary care.

Pollock S, Swamy M, Tremblay E, Shen L Pediatr Med. 2022; 5.

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Acanthosis Nigricans: Pointer of Endocrine Entities.

Radu A, Carsote M, Dumitrascu M, Sandru F Diagnostics (Basel). 2022; 12(10).

PMID: 36292208 PMC: 9600076. DOI: 10.3390/diagnostics12102519.

Prevalence of acanthosis nigricans and its association with physical activity in adolescents - School-based analytical cross-sectional study from Kochi, Kerala.

Sudevan R, Kumar S, Sunny C, Sunand N, Vasudevan A, S S J Family Med Prim Care. 2022; 10(11):4218-4222.

PMID: 35136792 PMC: 8797089. DOI: 10.4103/jfmpc.jfmpc_953_21.

Acanthosis Nigricans in Children and Adolescents with Type 1 Diabetes or Obesity: The Potential Interplay Role between Insulin Resistance and Excess Weight.

Calcaterra V, De Silvestri A, Schneider L, Acunzo M, Vittoni V, Meraviglia G Children (Basel). 2021; 8(8).

PMID: 34438601 PMC: 8391689. DOI: 10.3390/children8080710.

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