Cortical Actin Dynamics in Endothelial Permeability

Overview

Journal Curr Top Membr

Specialties Biochemistry
Cell Biology

Date 2018 Oct 27

PMID 30360779

Citations 26

Authors

Patrick Belvitch

Yu Maw Htwe

Mary E Brown

Steven Dudek

Affiliations

Soon will be listed here.

Abstract

The pulmonary endothelial cell forms a critical semi-permeable barrier between the vascular and interstitial space. As part of the blood-gas barrier in the lung, the endothelium plays a key role in normal physiologic function and pathologic disease. Changes in endothelial cell shape, defined by its plasma membrane, determine barrier integrity. A number of key cytoskeletal regulatory and effector proteins including non-muscle myosin light chain kinase, cortactin, and Arp 2/3 mediate actin rearrangements to form cortical and membrane associated structures in response to barrier enhancing stimuli. These actin formations support and interact with junctional complexes and exert forces to protrude the lipid membrane to and close gaps between individual cells. The current knowledge of these cytoskeletal processes and regulatory proteins are the subject of this review. In addition, we explore novel advancements in cellular imaging that are poised to shed light on the complex nature of pulmonary endothelial permeability.

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