Patrick Belvitch
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Explore the profile of Patrick Belvitch including associated specialties, affiliations and a list of published articles.
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20
Citations
257
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Recent Articles
1.
Hough R, Alvira C, Bastarache J, Erzurum S, Kuebler W, Schmidt E, et al.
Am J Respir Cell Mol Biol
. 2024 Aug;
71(4):388-406.
PMID: 39189891
Lung endothelium resides at the interface between the circulation and the underlying tissue, where it senses biochemical and mechanical properties of both the blood as it flows through the vascular...
2.
Sun X, Sun B, Sammani S, Dudek S, Belvitch P, Camp S, et al.
Biosci Rep
. 2024 Aug;
44(9).
PMID: 39162263
Rationale: Cortactin, an actin-binding cytoskeletal protein, plays a crucial role in maintaining endothelial cell (EC) barrier integrity and regulating vascular permeability. The gene encoding cortactin, CTTN, is implicated in various...
3.
Politowicz A, Burks A, Dong Y, Htwe Y, Dudek S, Marai G, et al.
BMC Pulm Med
. 2022 Dec;
22(1):480.
PMID: 36528564
Background: Acute lung injury and the acute respiratory distress syndrome are characterized by pulmonary inflammation, reduced endothelial barrier integrity and filling of the alveolar space with protein rich edema fluid...
4.
Bandela M, Belvitch P, Garcia J, Dudek S
Int J Mol Sci
. 2022 May;
23(9).
PMID: 35562995
Cortactin (CTTN) is an actin-binding and cytoskeletal protein that is found in abundance in the cell cortex and other peripheral structures of most cell types. It was initially described as...
5.
Belvitch P, Casanova N, Sun X, Camp S, Sammani S, Brown M, et al.
Transl Res
. 2022 Feb;
244:56-74.
PMID: 35181549
The cortactin gene (CTTN), encoding an actin-binding protein critically involved in cytoskeletal dynamics and endothelial cell (EC) barrier integrity, contains single nucleotide polymorphisms (SNPs) associated with severe asthma in Black...
6.
Wang L, Letsiou E, Wang H, Belvitch P, Meliton L, Brown M, et al.
Am J Physiol Lung Cell Mol Physiol
. 2022 Jan;
322(1):L149-L161.
PMID: 35015568
Disruption of the lung endothelial barrier is a hallmark of acute respiratory distress syndrome (ARDS), for which no effective pharmacologic treatments exist. Prior work has demonstrated that FTY720 S-phosphonate (Tys),...
7.
Htwe Y, Wang H, Belvitch P, Meliton L, Bandela M, Letsiou E, et al.
Cells
. 2021 Aug;
10(7).
PMID: 34359901
Lung endothelial dysfunction is a key feature of acute lung injury (ALI) and clinical acute respiratory distress syndrome (ARDS). Previous studies have identified the lipid-generating enzyme, group V phospholipase A2...
8.
Wong S, Tamatam C, Cho I, Toth P, Bargi R, Belvitch P, et al.
Nat Biomed Eng
. 2021 Jun;
6(1):54-66.
PMID: 34083763
The precise understanding and control of microenvironmental cues could be used to optimize the efficacy of cell therapeutics. Here, we show that mesenchymal stromal cells (MSCs) singly coated with a...
9.
Rizzo A, Belvitch P, Demeritte R, Garcia J, Letsiou E, Dudek S
Vascul Pharmacol
. 2020 Apr;
128-129:106677.
PMID: 32240815
Acute Respiratory Distress Syndrome (ARDS) is a devastating disease process that involves dysregulated inflammation and decreased alveolar-capillary barrier function. Despite increased understanding of the pathophysiology, no effective targeted therapies exist...
10.