Isolation and Characterization of Novel Reassortant H6N1 Avian Influenza Viruses from Chickens in Eastern China

Overview

Journal Virol J

Publisher Biomed Central

Specialty Microbiology

Date 2018 Oct 26

PMID 30355336

Citations 9

Authors

Haibo Wu

Fan Yang

Fumin Liu

Rufeng Lu

Xiuming Peng

Bin Chen

Hangping Yao

Nanping Wu

Affiliations

Soon will be listed here.

Abstract

Background: The H6N1 subtype of avian influenza viruses (AIVs) can infect people with an influenza-like illness; the H6N1 viruses possess the ability for zoonotic transmission from avians into mammals, and possibly pose a threat to human health.

Methods: In 2017, live poultry markets (LPMs) in Zhejiang Province were surveyed for AIVs. To better understand the genetic relationships between these strains from Eastern China and other AIVs, all gene segments of these strains were sequenced and compared with sequences available in GenBank. In this study, we analyzed the receptor-binding specificity, antigenic characteristics, and pathogenicity of these two H6N1 viruses.

Results: In 2017, two H6N1 AIVs were isolated from chickens during surveillance for AIVs in LPMs in Eastern China. Phylogenetic analysis showed that these strains shared genetic characteristics from H6, H10, H1, and H4 AIVs found in ducks and wild birds in East Asia. These AIV strains were able to replicate in mice without prior adaptation.

Conclusions: In this study, we report the discovery of new strains of H6N1 viruses from chickens with novel gene reassortments. Our results suggest that these chickens play an important role generating novel reassortments in AIVs, and emphasize the need for continued surveillance of AIV strains circulating in poultry.

Citing Articles

Evaluating the Impact of Low-Pathogenicity Avian Influenza H6N1 Outbreaks in United Kingdom and Republic of Ireland Poultry Farms during 2020.

McMenamy M, McKenna R, Bailie V, Cunningham B, Jeffers A, McCullough K Viruses. 2024; 16(7).

PMID: 39066308 PMC: 11281592. DOI: 10.3390/v16071147.

Genetic and virological characteristics of a reassortant avian influenza A H6N1 virus isolated from wild birds at a live-bird market in Egypt.

Kutkat O, Gomaa M, Aboulhoda B, Moatasim Y, El Taweel A, Kamel M Arch Virol. 2024; 169(5):95.

PMID: 38594485 DOI: 10.1007/s00705-024-06022-6.

Avian H6 Influenza Viruses in Vietnamese Live Bird Markets during 2018-2021.

Guan L, Babujee L, Presler R, Pattinson D, Nguyen H, Hoang V Viruses. 2024; 16(3).

PMID: 38543733 PMC: 10975462. DOI: 10.3390/v16030367.

Wild Bird-Origin H6N2 Influenza Virus Acquires Enhanced Pathogenicity after Single Passage in Mice.

Tang S, Han B, Su C, Li H, Zhao S, Leng H Viruses. 2024; 16(3).

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A multiplex TaqMan real-time RT-PCR assay for the simultaneous detection of H4, H6, and H10 avian influenza viruses.

Yang F, Yan S, Zhu L, Yao H, Dong D, Wu D Heliyon. 2023; 9(5):e15647.

PMID: 37153423 PMC: 10160747. DOI: 10.1016/j.heliyon.2023.e15647.

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