Circular RNA Expression in Oral Squamous Cell Carcinoma

Overview

Journal Front Oncol

Specialty Oncology

Date 2018 Oct 24

PMID 30349810

Citations 24

Authors

Yu-Fan Wang

Bo-Wen Li

Shuai Sun

Xiang Li

Wen Su

Zhi-Hong Wang

Feng Wang

Wei Zhang

Hong-Yu Yang

Affiliations

Soon will be listed here.

Abstract

Circular RNA (circRNA) is a type of non-coding RNA molecule that affects the cellular regulatory network by sequestering microRNA (miRNA) like a sponge. This study was performed to identify differentially-expressed circRNA in oral squamous cell carcinomas (OSCCs). By high-throughput sequencing, microarray circRNA expression profiles were acquired from patients with OSCCs ( = 8) and controls ( = 8), which totaled 1921 existing circRNA molecules and 10021 novel circRNA molecules. Most of the circular RNA is from exons and distributed in the No. 1 and 2 chromosomes. Eight up-regulated and down-regulated circRNA molecules were identified as differentially-expressed in OSCCs. Among this, the expression of circ_000334, circ_006740, and circ_006371 are significantly down-regulated in 42 pairs of samples, which means that these circRNA molecules might be implicated in oncogenesis and development of OSCCs.

Citing Articles

Non-coding RNAs in oral cancer: Emerging biomarkers and therapeutic frontier.

Hashemi M, Khoushab S, Hobabi Aghmiuni M, Anaraki S, Alimohammadi M, Taheriazam A Heliyon. 2024; 10(21):e40096.

PMID: 39583806 PMC: 11582460. DOI: 10.1016/j.heliyon.2024.e40096.

Noncanonical formation of SNX5 gene-derived circular RNA regulates cancer growth.

Chen Y, Tsai H, Kan C, Ma C, Chen H, Yi-Feng Chang I Cell Death Dis. 2024; 15(8):599.

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CircRNAs: A Promising Star for Treatment and Prognosis in Oral Squamous Cell Carcinoma.

Zhu M, Chen D, Ruan C, Yang P, Zhu J, Zhang R Int J Mol Sci. 2023; 24(18).

PMID: 37762497 PMC: 10532269. DOI: 10.3390/ijms241814194.

Identification of circular RNA_0000919 as a potential diagnostic and prognostic biomarker of tongue squamous cell carcinoma using circular RNA microarray and reverse transcription-quantitative PCR analyses.

Liu H, Li Q, Qi H, Du F, Qiu Y Oncol Lett. 2022; 24(2):270.

PMID: 35782902 PMC: 9247670. DOI: 10.3892/ol.2022.13390.

Circular RNA circSPATA6 Inhibits the Progression of Oral Squamous Cell Carcinoma Cells by Regulating TRAF6 via miR-182.

Fan X, Wang Y Cancer Manag Res. 2021; 13:1817-1829.

PMID: 33654430 PMC: 7910102. DOI: 10.2147/CMAR.S292074.

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