CircPHIP Promotes Oral Squamous Cell Carcinoma Progression by Sponging MiR-142-5p and Regulating PHIP and ACTN4 Expression

Overview

Journal Mol Ther Nucleic Acids

Publisher Cell Press

Date 2020 Dec 30

PMID 33376626

Citations 7

Authors

Wen Su

Yuehong Shen

Yufan Wang

Feng Wang

Xia Hong

Yuling Chen

Yuntao Lin

Hongyu Yang

Affiliations

Soon will be listed here.

Abstract

Circular RNA (circRNA) is a newly discovered class of noncoding RNAs that plays key regulatory role in pathological development, including the regulation of several solid tumors. However, the effects of circRNA expression on oral squamous cell carcinoma (OSCC) remain unclear. With the use of high-throughput RNA sequencing data on eight paired oral cancer and adjacent healthy tissues, we observed that circRNA derived from the gene encoding pleckstrin homology domain-interacting protein (circPHIP) was highly expressed in OSCC. Additionally, circPHIP was highly expressed in other OSCC-related cell lines and was associated with tumor metastasis, TNM stage, and human papilloma virus infection status. The inhibition of circPHIP expression reduced OSCC cell migration, invasion, and proliferation. We found that circPHIP could adsorb microRNA (miR)-142-5p and upregulate the expression of PHIP and alpha-actinin 4 (ACTN4), both of which are potential oncogenes closely related to OSCC prognosis. The inhibition of miR-142-5p or overexpressing PHIP or ACTN4 reversed the circPHIP depletion-induced attenuation of OSCC malignancy. In conclusion, circPHIP is overexpressed in OSCC and enhances its malignancy via an miR-142-5p/PHIP-ACTN4/AKT serine/threonine kinase 1 signaling axis. Therefore, circPHIP may represent a novel target for treating OSCC.

Citing Articles

Hsa_circ_0001615 downregulation inhibits esophageal cancer development through miR-142-5p/β-catenin.

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circNFATC3 facilitated the progression of oral squamous cell carcinoma via the miR-520h/LDHA axis.

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Identification of key miRNAs and targeted genes involved in the progression of oral squamous cell carcinoma.

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circ3323 Motivates Host Gene to Promote the Aggressiveness of Bladder Cancer.

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Hsa-circ-0007292 promotes the osteogenic differentiation of posterior longitudinal ligament cells via regulating SATB2 by sponging miR-508-3p.

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