Efficacy and Safety of Iodine-125 Brachytherapy Combined with Chemotherapy in the Treatment of Advanced NSCLC in the Elderly

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2018 Oct 24

PMID 30349295

Citations 9

Authors

Chunrong Wu

Bo Li

Guiyin Sun

Chunfang Peng

Debing Xiang

Affiliations

Soon will be listed here.

Abstract

Background: Advanced non-small-cell lung cancer (NSCLC) is a huge challenge for physicians. Traditional chemoradiotherapy is associated with high rates of toxicities, especially when treating gerontal patients. Our study was focused on investigating the safety and efficacy of permanent iodine-125 seed implantation and chemotherapy for the treatment of advanced NSCLC in the elderly.

Methods: Fifty elderly patients with stage III or IV NSCLC at our hospital from January 2011 to June 2017 were treated with the chemotherapy regimens (paclitaxel/cisplatin) and computed tomography (CT)-guided iodine-125 brachytherapy (group A), 50 patients who received chemotherapy consisting of paclitaxel and cisplatin only (group B) were matched-up with the patients in group A. The local response rate was evaluated by CT. Progression-free survival (PFS) and overall survival (OS) data were obtained through clinical follow-up.

Results: The patients were followed-up for 3-46 months. With a median follow-up time of 20 months, the OS and PFS were 20 months (95% CI: 19.09-20.90 months) vs 15 months (95% CI: 14.48-15.51 months) (<0.05) and 13 months (95% CI: 11.96-14.04 months) vs 8 months (95% CI: 7.63-8.37 months) (<0.05) in group A and group B, respectively. The symptoms of patients in group A were significantly relieved when compared with group B. Severe complications were not observed in either of the groups.

Conclusion: The combination of iodine-125 seed brachytherapy and chemotherapy is an effective and safe therapy and is superior to chemotherapy alone for advanced NSCLC in the elderly.

Citing Articles

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I-125 seeds brachytherapy combined with immunotherapy for MET amplification in non-small cell lung cancer from clinical application to related lncRNA mechanism explore: a case report.

Yang M, You Y, Wang X, Dong W Front Cell Dev Biol. 2023; 11:1176083.

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Radioactive Iodine-125 in Tumor Therapy: Advances and Future Directions.

Wei S, Li C, Li M, Xiong Y, Jiang Y, Sun H Front Oncol. 2021; 11:717180.

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Efficacy and Safety Aiming at the Combined-Modality Therapy of External Beam Radiotherapy (40Gy) and Iodine-125 Seed Implantation for Locally Advanced NSCLC in the Elderly.

Tian L, Liu H, Zhang Q, Geng D, Huo Y, Xu S Cancer Manag Res. 2021; 13:5457-5466.

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The Clinical Value of Computed Tomography (CT)-Guided I Brachytherapy for Locally Advanced Non-Small Cell Lung Cancer After Progression of Concurrent Radiochemotherapy.

Xiang Z, Zhong Z, Mu L, Li G, Zhou C, Wang H Cancer Manag Res. 2021; 13:5297-5307.

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