Metabolic Profile of Patients with Premature Ovarian Insufficiency

Overview

Journal J Clin Med

Specialty General Medicine

Date 2018 Oct 24

PMID 30347864

Citations 16

Authors

Agnieszka Podfigurna

Angelika Stellmach

Anna Szeliga

Adam Czyzyk

Blazej Meczekalski

Affiliations

Soon will be listed here.

Abstract

Materials And Methods: Follicle stimulating hormone (FSH), luteinizing hormone (LH), 17β-estradiol (E2), prolactin (PRL), testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), thyroid stimulating hormone (TSH), thyroxine (fT4), fasting serum glucose and insulin concentrations, homeostatic model for insulin resistance (HOMA-IR), and lipid profiles were assessed in 56 women (mean age: 30.7 6.9) suffering from POI diagnosed according to European Society of Human Reproduction and Embryology (ESHRE) criteria and 68 healthy age-and-weight matched women (mean age: 27.3 4.5).

Results: After regression analysis with BMI and age correction, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) serum concentrations were found to be significantly higher in the POI group, when compared to healthy subjects, whilst triglycerides, glucose, insulin serum concentrations, HOMA-IR, as well as systolic (SBP) and diastolic blood pressure (DBP) did not differ significantly between both groups. A significant positive correlation was identified between TC and LDL-C levels, regardless of BMI and age, whilst SBP correlated only with serum glucose concentration. Additionally, FSH correlated positively with fasting serum glucose concentration after BMI and age correction.

Conclusions: Certain metabolic parameters appeared to correlate with POI and these correlations persisted after correction for BMI and age. More research is required to determine the influence of absent ovulatory function on metabolic profiles in POI women. This information may additionally help in early identification of CVD risk factors in those patients.

Citing Articles

Causal association between metabolic syndrome and ovarian dysfunction: a bidirectional two-sample mendelian randomization.

He Y, Wei Y, Liang H, Wan Y, Zhang Y, Zhang J J Ovarian Res. 2025; 18(1):50.

PMID: 40069881 PMC: 11895234. DOI: 10.1186/s13048-025-01614-5.

Metabolic Risk in Patients with a Diminished Ovarian Reserve and Premature Ovarian Insufficiency.

Robeva R, Elenkova A, Kirilov G, Zacharieva S J Clin Med. 2024; 13(17).

PMID: 39274315 PMC: 11396120. DOI: 10.3390/jcm13175105.

Cyclophosphamide induces ovarian granulosa cell ferroptosis via a mechanism associated with HO-1 and ROS-mediated mitochondrial dysfunction.

Chen H, Nie P, Li J, Wu Y, Yao B, Yang Y J Ovarian Res. 2024; 17(1):107.

PMID: 38762721 PMC: 11102268. DOI: 10.1186/s13048-024-01434-z.

Protective role of stem cells in POI: Current status and mechanism of action, a review article.

Sadeghi S, Mosaffa N, Huang B, Ramezani Tehrani F Heliyon. 2024; 10(1):e23271.

PMID: 38169739 PMC: 10758796. DOI: 10.1016/j.heliyon.2023.e23271.

What Do Higher Alanine Aminotransferase Levels Mean in Premature Ovarian Insufficiency?.

Wang W, Cheng X, Yao J, Xue H, Li C, Wang X Reprod Sci. 2023; 31(2):469-479.

PMID: 37723330 DOI: 10.1007/s43032-023-01303-y.

References

Luborsky J, Meyer P, Sowers M, Gold E, Santoro N . Premature menopause in a multi-ethnic population study of the menopause transition. Hum Reprod. 2003; 18(1):199-206. DOI: 10.1093/humrep/deg005. View

Vujovic S, Brincat M, Erel T, Gambacciani M, Lambrinoudaki I, Moen M . EMAS position statement: Managing women with premature ovarian failure. Maturitas. 2010; 67(1):91-3. DOI: 10.1016/j.maturitas.2010.04.011. View

Do K, Green A, Guthrie J, Dudley E, Burger H, Dennerstein L . Longitudinal study of risk factors for coronary heart disease across the menopausal transition. Am J Epidemiol. 2000; 151(6):584-93. DOI: 10.1093/oxfordjournals.aje.a010246. View

Kulaksizoglu M, Ipekci S, Kebapcilar L, Kebapcilar A, Korkmaz H, Akyurek F . Risk factors for diabetes mellitus in women with primary ovarian insufficiency. Biol Trace Elem Res. 2013; 154(3):313-20. DOI: 10.1007/s12011-013-9738-0. View

Knauff E, Westerveld H, Goverde A, Eijkemans M, Valkenburg O, van Santbrink E . Lipid profile of women with premature ovarian failure. Menopause. 2008; 15(5):919-23. DOI: 10.1097/gme.0b013e31816b4509. View

Wellons M . Cardiovascular disease and primary ovarian insufficiency. Semin Reprod Med. 2011; 29(4):328-41. PMC: 3353811. DOI: 10.1055/s-0031-1280918. View

Ates S, Yesil G, Sevket O, Molla T, Yildiz S . Comparison of metabolic profile and abdominal fat distribution between karyotypically normal women with premature ovarian insufficiency and age matched controls. Maturitas. 2014; 79(3):306-10. DOI: 10.1016/j.maturitas.2014.07.008. View

van der Schouw Y, Van der Graaf Y, Steyerberg E, Eijkemans J, Banga J . Age at menopause as a risk factor for cardiovascular mortality. Lancet. 1996; 347(9003):714-8. DOI: 10.1016/s0140-6736(96)90075-6. View

Kim C, Kim T, Ryu W, Ryoo U . Influence of menopause on high density lipoprotein-cholesterol and lipids. J Korean Med Sci. 2000; 15(4):380-6. PMC: 3054669. DOI: 10.3346/jkms.2000.15.4.380. View

10.

Fenton A . Premature ovarian insufficiency: Pathogenesis and management. J Midlife Health. 2016; 6(4):147-53. PMC: 4743275. DOI: 10.4103/0976-7800.172292. View

11.

Timmreck L, Reindollar R . Contemporary issues in primary amenorrhea. Obstet Gynecol Clin North Am. 2003; 30(2):287-302. DOI: 10.1016/s0889-8545(03)00027-5. View

12.

Chang S, Kim C, Lee K, Kim H, Yim S, Lim Y . Premenopausal factors influencing premature ovarian failure and early menopause. Maturitas. 2007; 58(1):19-30. DOI: 10.1016/j.maturitas.2007.04.001. View

13.

Kalantaridou S, Naka K, Papanikolaou E, Kazakos N, Kravariti M, Calis K . Impaired endothelial function in young women with premature ovarian failure: normalization with hormone therapy. J Clin Endocrinol Metab. 2004; 89(8):3907-13. DOI: 10.1210/jc.2004-0015. View

14.

Webber L, Davies M, Anderson R, Bartlett J, Braat D, Cartwright B . ESHRE Guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2016; 31(5):926-37. DOI: 10.1093/humrep/dew027. View

15.

Daan N, Muka T, Koster M, Roeters van Lennep J, Lambalk C, Laven J . Cardiovascular Risk in Women With Premature Ovarian Insufficiency Compared to Premenopausal Women at Middle Age. J Clin Endocrinol Metab. 2016; 101(9):3306-15. DOI: 10.1210/jc.2016-1141. View

16.

Abdulnour J, Doucet E, Brochu M, Lavoie J, Strychar I, Rabasa-Lhoret R . The effect of the menopausal transition on body composition and cardiometabolic risk factors: a Montreal-Ottawa New Emerging Team group study. Menopause. 2012; 19(7):760-7. DOI: 10.1097/gme.0b013e318240f6f3. View

17.

Corrigan E, Nelson L, Bakalov V, Yanovski J, Vanderhoof V, Yanoff L . Effects of ovarian failure and X-chromosome deletion on body composition and insulin sensitivity in young women. Menopause. 2006; 13(6):911-6. DOI: 10.1097/01.gme.0000248702.25259.00. View

18.

Jacobsen B, Nilssen S, Heuch I, Kvale G . Does age at natural menopause affect mortality from ischemic heart disease?. J Clin Epidemiol. 1997; 50(4):475-9. DOI: 10.1016/s0895-4356(96)00425-8. View

19.

Podfigurna-Stopa A, Czyzyk A, Grymowicz M, Smolarczyk R, Katulski K, Czajkowski K . Premature ovarian insufficiency: the context of long-term effects. J Endocrinol Invest. 2016; 39(9):983-90. PMC: 4987394. DOI: 10.1007/s40618-016-0467-z. View

20.

Coulam C, Adamson S, Annegers J . Incidence of premature ovarian failure. Obstet Gynecol. 1986; 67(4):604-6. View