Local Tandem Repeat Expansion in RNA As a Model for the Functionalisation of NcRNA

Overview

Journal Noncoding RNA

Date 2018 Oct 24

PMID 30347781

Citations 15

Authors

Neil Brockdorff

Affiliations

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Abstract

, the master regulator of the X chromosome inactivation in mammals, is a 17 kb lncRNA that acts to silence the majority of genes along the chromosome from which it is transcribed. The two key processes required for RNA function, localisation and recruitment of silencing factors, are genetically separable, at least in part. Recent studies have identified RNA sequences and associated RNA-binding proteins (RBPs) that are important for these processes. Notably, several of the key RNA elements correspond to local tandem repeats. In this review, I use examples to illustrate different modes whereby tandem repeat amplification has been exploited to allow orthodox RBPs to confer new functions for -mediated chromosome inactivation. I further discuss the potential generality of tandem repeat expansion in the evolution of functional long non-coding RNAs (lncRNAs).

Citing Articles

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Unraveling the role of Xist in X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A.

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