γ-Tubulin⁻γ-Tubulin Interactions As the Basis for the Formation of a Meshwork

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Oct 24

PMID 30347727

Citations 13

Authors

Catalina Ana Rossello

Lisa Lindstrom

Greta Eklund

Matthieu Corvaisier

Maria Alvarado Kristensson

Affiliations

Soon will be listed here.

Abstract

In cytoplasm, protein γ-tubulin joins with various γ-tubulin complex proteins (GCPs) to form a heterotetramer γ-tubulin small complex (γ-TuSC) that can grow into a ring-shaped structure called the γ-tubulin ring complex (γ-TuRC). Both γ-TuSC and γ-TuRC are required for microtubule nucleation. Recent knowledge on γ-tubulin with regard to its cellular functions beyond participation in its creation of microtubules suggests that this protein forms a cellular meshwork. The present review summarizes the recognized functions of γ-tubulin and aims to unite the current views on this protein.

Citing Articles

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Molecular characterization of the TUBG1 meshwork's influence on Cytoskeletal organization.

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