Diurnal Variation of Autophagy in Rod Visual Cells in the Rat

Overview

Journal Albrecht Von Graefes Arch Klin Exp Ophthalmol

Specialty Ophthalmology

Date 1977 Sep 28

PMID 303474

Citations 26

Authors

C E Reme

M Sulser

Affiliations

Soon will be listed here.

Abstract

In the process of autophagy, parts of the cell's own cytoplasm are enclosed by membranes and subsequently digested by enzymes. Autophagy is a well-known process found in various tissues under different conditions (See Refs.). Autophagy in visual cells was first documented by Remé and Young (1977) and Remé (1977), and was considered to be a general and important degradative pathway in visual cell metabolism. Recently, La Vail (1976) demonstrated that the shedding of disks from the tips of rod outer segments followed a circadian rhythm in rats. The peak period of disk shedding occurred shortly after the onset of the lighting period. In this study we have demonstrated, by quantitative analysis, that autophagy in rod inner segments follows a diurnal variation. The peak period of autophagic activity occurs about 3 h after the peak period of disk-shedding. Both peak periods take place in daytime, when the animals are less active. This finding further supports our assumption of autophagy being an important pathway in visual cell degradative mechanisms.

Citing Articles

Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease.

Morrone C, Raghuraman R, Hussaini S, Yu W Mol Neurodegener. 2023; 18(1):27.

PMID: 37085942 PMC: 10119020. DOI: 10.1186/s13024-023-00617-4.

AUTOPHAGY IN THE EYE: FROM PHYSIOLOGY TO PATHOPHYSOLOGY.

Liton P, Boesze-Battaglia K, Boulton M, Boya P, Ferguson T, Ganley I Autophagy Rep. 2023; 2(1).

PMID: 37034386 PMC: 10078619. DOI: 10.1080/27694127.2023.2178996.

Conditional Knock out of High-Mobility Group Box 1 (HMGB1) in Rods Reduces Autophagy Activation after Retinal Detachment.

Ross B, Jia L, Kong D, Wang T, Hager H, Abcouwer S Cells. 2021; 10(8).

PMID: 34440779 PMC: 8394251. DOI: 10.3390/cells10082010.

Diurnal Rhythmicity of Autophagy Is Impaired in the Diabetic Retina.

Qi X, Mitter S, Yan Y, Busik J, Grant M, Boulton M Cells. 2020; 9(4).

PMID: 32272782 PMC: 7226792. DOI: 10.3390/cells9040905.

Phosphoinositides in Retinal Function and Disease.

Wensel T Cells. 2020; 9(4).

PMID: 32252387 PMC: 7226789. DOI: 10.3390/cells9040866.

References

Young R, Bok D . Participation of the retinal pigment epithelium in the rod outer segment renewal process. J Cell Biol. 1969; 42(2):392-403. PMC: 2107669. DOI: 10.1083/jcb.42.2.392. View

Berman E, SCHWELL H, Feeney L . The retinal pigment epithelium. Chemical composition and structure. Invest Ophthalmol. 1974; 13(9):675-87. View

Young R . Visual cells and the concept of renewal. Invest Ophthalmol Vis Sci. 1976; 15(9):700-25. View

Fedorko M, Hirsch J, COHN Z . Autophagic vacuoles produced in vitro. I. Studies on cultured macrophages exposed to chloroquine. J Cell Biol. 1968; 38(2):377-91. PMC: 2107491. DOI: 10.1083/jcb.38.2.377. View

DE DUVE C . The lysosome. Sci Am. 1963; 208:64-72. DOI: 10.1038/scientificamerican0563-64. View

LaVail M . Rod outer segment disk shedding in rat retina: relationship to cyclic lighting. Science. 1976; 194(4269):1071-4. DOI: 10.1126/science.982063. View

Young R . The renewal of photoreceptor cell outer segments. J Cell Biol. 1967; 33(1):61-72. PMC: 2107286. DOI: 10.1083/jcb.33.1.61. View

DE DUVE C, WATTIAUX R . Functions of lysosomes. Annu Rev Physiol. 1966; 28:435-92. DOI: 10.1146/annurev.ph.28.030166.002251. View

Pfeifer U . [Problems of cellular autophagy. Morphological, enzyme cytochemical and quantitative studies in normal and altered rat liver cells]. Ergeb Anat Entwicklungsgesch. 1971; 44(4):1-74. View

10.

Pfeifer U . [Morphological and functional aspects of cellular autophagy]. Acta Morphol Acad Sci Hung. 1972; 20(3):247-67. View

11.

ARSTILA A, Nuuja I, Trump B . Studies on cellular autophagocytosis. Vinblastine-induced autophagy in the rat liver. Exp Cell Res. 1974; 87(2):249-52. DOI: 10.1016/0014-4827(74)90477-7. View

12.

Locke M, Sykes A . The role of the Golgi complex in the isolation and digestion of organelles. Tissue Cell. 1975; 7(1):143-58. DOI: 10.1016/s0040-8166(75)80012-7. View

13.

Young R . The renewal of rod and cone outer segments in the rhesus monkey. J Cell Biol. 2009; 49(2):303-18. PMC: 2108322. DOI: 10.1083/jcb.49.2.303. View

14.

Reme C, Young R . The effects of hibernation on cone visual cells in the ground squirrel. Invest Ophthalmol Vis Sci. 1977; 16(9):815-40. View

15.

Young R . Shedding of discs from rod outer segments in the rhesus monkey. J Ultrastruct Res. 1971; 34(1):190-203. DOI: 10.1016/s0022-5320(71)90014-1. View

16.

Fedorko M, Hirsch J, COHN Z . Autophagic vacuoles produced in vitro. II. Studies on the mechanism of formation of autophagic vacuoles produced by chloroquine. J Cell Biol. 1968; 38(2):392-402. PMC: 2107481. DOI: 10.1083/jcb.38.2.392. View

17.

Young R . The daily rhythm of shedding and degradation of cone outer segment membranes in the lizard retina. J Ultrastruct Res. 1977; 61(2):172-85. DOI: 10.1016/s0022-5320(77)80084-1. View

18.

Pfeifer U, Scheller H . A morphometric study of cellular autophagy including diurnal variations in kidney tubules of normal rats. J Cell Biol. 1975; 64(3):608-21. PMC: 2109538. DOI: 10.1083/jcb.64.3.608. View

19.

Pfeifer U . Cellular autophagy and cell atrophy in the rat liver during long-term starvation. A quantitative morphological study with regard to diurnal variations. Virchows Arch B Cell Pathol. 1973; 12(3):195-211. DOI: 10.1007/BF02893998. View

20.

Feeney L . The interphotoreceptor space. I. Postnatal ontogeny in mice and rats. Dev Biol. 1973; 32(1):101-14. DOI: 10.1016/0012-1606(73)90223-6. View