A Time to Reap, a Time to Sow: Mitophagy and Biogenesis in Cardiac Pathophysiology

Overview

Journal J Mol Cell Cardiol

Specialty Cardiology & Vascular Diseases

Date 2014 Dec 3

PMID 25444712

Citations 30

Authors

Allen M Andres

Aleksandr Stotland

Bruno B Queliconi

Roberta A Gottlieb

Affiliations

Soon will be listed here.

Abstract

Balancing mitophagy and mitochondrial biogenesis is essential for maintaining a healthy population of mitochondria and cellular homeostasis. Coordinated interplay between these two forces that govern mitochondrial turnover plays an important role as an adaptive response against various cellular stresses that can compromise cell survival. Failure to maintain the critical balance between mitophagy and mitochondrial biogenesis or homeostatic turnover of mitochondria results in a population of dysfunctional mitochondria that contribute to various disease processes. In this review we outline the mechanics and relationships between mitophagy and mitochondrial biogenesis, and discuss the implications of a disrupted balance between these two forces, with an emphasis on cardiac physiology. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease".

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