Systems and Synthetic Biology Approaches to Engineer Fungi for Fine Chemical Production

Overview

Journal Front Bioeng Biotechnol

Date 2018 Oct 20

PMID 30338257

Citations 12

Authors

Leonardo Martins-Santana

Luisa C Nora

Ananda Sanches-Medeiros

Gabriel L Lovate

Murilo H A Cassiano

Rafael Silva-Rocha

Affiliations

Soon will be listed here.

Abstract

Since the advent of systems and synthetic biology, many studies have sought to harness microbes as cell factories through genetic and metabolic engineering approaches. Yeast and filamentous fungi have been successfully harnessed to produce fine and high value-added chemical products. In this review, we present some of the most promising advances from recent years in the use of fungi for this purpose, focusing on the manipulation of fungal strains using systems and synthetic biology tools to improve metabolic flow and the flow of secondary metabolites by pathway redesign. We also review the roles of bioinformatics analysis and predictions in synthetic circuits, highlighting systemic approaches to improve the efficiency of synthetic modules.

Citing Articles

Considerations for Domestication of Novel Strains of Filamentous Fungi.

Pullen R, Decker S, Subramanian V, Adler M, Tobias A, Perisin M ACS Synth Biol. 2025; 14(2):343-362.

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FungalBraid 2.0: expanding the synthetic biology toolbox for the biotechnological exploitation of filamentous fungi.

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Mining novel -regulatory elements from the emergent host using transcriptomic data.

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Begum N, Harzandi A, Lee S, Uhlen M, Moyes D, Shoaie S Gut Microbes. 2022; 14(1):2121576.

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