Trained Females Exhibit Less Fatigability Than Trained Males After a Heavy Knee Extensor Resistance Exercise Session

Purpose: We examined differences between trained males and females in measures of muscular fatigability and central motor output after a resistance exercise session.

Methods: Sixteen trained males (n = 8) and females (n = 8) participated in the study. Knee extensor maximal torque and rate of torque development were measured before and after the exercise session, and the twitch interpolation technique was used during the maximal efforts to derive measures of voluntary activation and muscle contractility by supramaximal stimulation of the femoral nerve using 10 and 100 Hz doublets. Surface electromyograms were recorded during all maximal efforts to examine maximal and rate of quadriceps muscle activation.

Results: After exercise, maximal torque was reduced for both sexes by 26.3 ± 12.5% (p < 0.001). Absolute and relative vRTD was reduced only for males after exercise (p < 0.05). The early (0-50 ms) rate of muscle activation rise was similarly reduced for both sexes between 2.6 and 16.4% s (p < 0.01), but males experienced an average decrease of 82.5 ± 72.1% s for the maximal rate of muscle activation compared to no change for females (p = 0.02). Males had greater reductions (p < 0.05) for maximal twitch amplitudes and rate of twitch development (- 51.1 ± 21.5% and - 49.9 ± 22.8%, respectively) compared to females (- 35.8 ± 13.7% and - 31.5 ± 14.0%, respectively).

Conclusions: These findings suggest that trained females are resistant to reductions in rapid torque development, despite similar reductions in maximal torque, after resistance exercise, with this result explained by better-maintained muscle contractility and maximal rate of muscle activation compared to males.