Associations Between Radius Low-frequency Axial Ultrasound Velocity and Bone Fragility in Elderly Men and Women

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2018 Oct 12

PMID 30306224

Citations 12

Authors

E Biver

J Pepe

A De Sire

T Chevalley

S Ferrari

Affiliations

Soon will be listed here.

Abstract

Methods: Low-frequency velocity (V) was measured at the radius using OsCare Sono®, a portable axial transmission ultrasonometer, in 271 community-dwelling postmenopausal women and men (age 71.5 ± 1.4 years) from the Geneva Retirees Cohort. Cortical (Ct) and trabecular (Tb) volumetric (v) BMD and microstructure at the distal radius were assessed by HR-pQCT, in addition to areal (a) BMD by DXA, at the same time point.

Results: V was highly correlated with aBMD at the distal third radius (r = 0.72, p < 0.001). For microstructure parameters, the highest correlation was observed with cortical area (r = 0.59, p < 0.001). V also captured bone geometry (total area) and cortical tissue mineral density independently of aBMD. In models adjusted for age and sex, V was significantly associated with prevalent low-trauma fractures [OR 95%CI for one SD decrease of V 1.50 (1.05, 2.14), p = 0.024], with discrimination performance comparable to femoral neck or distal radius aBMD.

Conclusion: Measurement of V at the radius captures aBMD, bone size, and cortical tissue mineral density and might be used for screening purposes prior to DXA to evaluate fracture risk

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