Tired and Stressed: Examining the Need for Sleep

Overview

Journal Eur J Neurosci

Specialty Neurology

Date 2018 Oct 9

PMID 30295966

Citations 11

Authors

Vanessa M Hill

Reed M OConnor

Mimi Shirasu-Hiza

Affiliations

Soon will be listed here.

Abstract

A key feature of circadian rhythms is the sleep/wake cycle. Sleep causes reduced responsiveness to the environment, which puts animals in a particularly vulnerable state; yet sleep has been conserved throughout evolution, indicating that it fulfils a vital purpose. A core function of sleep across species has not been identified, but substantial advances in sleep research have been made in recent years using the genetically tractable model organism, Drosophila melanogaster. This review describes the universality of sleep, the regulation of sleep, and current theories on the function of sleep, highlighting a historical and often overlooked theory called the Free Radical Flux Theory of Sleep. Additionally, we summarize our recent work with short-sleeping Drosophila mutants and other genetic and pharmacological tools for manipulating sleep which supports an antioxidant theory of sleep and demonstrates a bi-directional relationship between sleep and oxidative stress.

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