Association Between Clusterin Concentration and Dementia: a Systematic Review and Meta-analysis

Overview

Journal Metab Brain Dis

Publisher Springer

Specialties Endocrinology
Neurology

Date 2018 Oct 7

PMID 30291488

Citations 17

Authors

Caiping Yang

Hai Wang

Chaojiu Li

Huiyan Niu

Shunkui Luo

Xingzhi Guo

Affiliations

Soon will be listed here.

Abstract

Studies have showed that high clusterin (CLU) concentration was associated with increased risk of dementia. However, the results based on small samples remained controversial. The aim of our study was to determine the relationship between CLU concentration and the late-life cognitive outcomes including mild cognitive impairment (MCI), Alzheimer's disease (AD), vascular dementia (VAD), Parkinson's disease related dementia (PDD), Lewy body dementia (DLB) and frontotemporal dementia (FTD). A comprehensive search was conducted to screen the eligible studies in online database PubMed, Web of Science and Embase from 1950 to January 2017 according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) checklist. The CLU concentration data in brain tissue, cerebrospinal fluid (CSF), serum and plasma was collected to determine the strength of this association. The results were presented with standard difference of the mean (SDM) with 95% confidence intervals (CIs). A total of 28 studies were identified to calculate the association between CLU concentration and dementia. The results showed that the CLU concentration in the plasma (SDM = 0.73, 95% CI 0.26-1.19, P = 0.002) and brain tissue (SDM = 0.71, 95% CI 0.10-1.32, P = 0.022) was increased in dementia compared to normal control. Subgroup analysis showed that the plasma CLU concentration was significantly increased only in the AD group (SDM = 1.85, 95% CI 0.84-2.85, P < 0.001), but not in MCI or other dementias. No association was found between serum and CSF clusterin concentration and dementia. This meta-analysis indicates that high CLU concentration in the plasma and brain is associated with dementia, especially in AD.

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References

Nilselid A, Davidsson P, Nagga K, Andreasen N, Fredman P, Blennow K . Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms. Neurochem Int. 2006; 48(8):718-28. DOI: 10.1016/j.neuint.2005.12.005. View

Xing Y, Yu J, Cui W, Zhong X, Wu Z, Zhang Q . Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's disease. J Alzheimers Dis. 2012; 29(3):515-9. DOI: 10.3233/JAD-2011-111844. View

Savkovic V, Gantzer H, Reiser U, Selig L, Gaiser S, Sack U . Clusterin is protective in pancreatitis through anti-apoptotic and anti-inflammatory properties. Biochem Biophys Res Commun. 2007; 356(2):431-7. DOI: 10.1016/j.bbrc.2007.02.148. View

Dukic L, Simundic A, Martinic-Popovic I, Kackov S, Diamandis A, Begcevic I . The role of human kallikrein 6, clusterin and adiponectin as potential blood biomarkers of dementia. Clin Biochem. 2015; 49(3):213-8. DOI: 10.1016/j.clinbiochem.2015.10.014. View

Vishnu V, Modi M, Sharma S, Mohanty M, Goyal M, Lal V . Role of Plasma Clusterin in Alzheimer's Disease-A Pilot Study in a Tertiary Hospital in Northern India. PLoS One. 2016; 11(11):e0166369. PMC: 5115728. DOI: 10.1371/journal.pone.0166369. View

Meng Y, Li H, Hua R, Wang H, Lu J, Yu X . A correlativity study of plasma APL1β28 and clusterin levels with MMSE/MoCA/CASI in aMCI patients. Sci Rep. 2015; 5:15546. PMC: 4621490. DOI: 10.1038/srep15546. View

Cai R, Han J, Sun J, Huang R, Tian S, Shen Y . Plasma Clusterin and the CLU Gene rs11136000 Variant Are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients. Front Aging Neurosci. 2016; 8:179. PMC: 4963458. DOI: 10.3389/fnagi.2016.00179. View

Zhou Y, Hayashi I, Wong J, Tugusheva K, Renger J, Zerbinatti C . Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. PLoS One. 2014; 9(7):e103187. PMC: 4106906. DOI: 10.1371/journal.pone.0103187. View

Solomon A, Soininen H . Dementia: Risk prediction models in dementia prevention. Nat Rev Neurol. 2015; 11(7):375-7. DOI: 10.1038/nrneurol.2015.81. View

10.

Shuai P, Liu Y, Lu W, Liu Q, Li T, Gong B . Genetic associations of CLU rs9331888 polymorphism with Alzheimer's disease: A meta-analysis. Neurosci Lett. 2015; 591:160-165. DOI: 10.1016/j.neulet.2015.02.040. View

11.

Schurmann B, Wiese B, Bickel H, Weyerer S, Riedel-Heller S, Pentzek M . Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration. J Alzheimers Dis. 2011; 25(3):421-4. DOI: 10.3233/JAD-2011-110251. View

12.

Lu S, Li H, Sun Y, Liu Z, Yang P, Wu Z . Clusterin variants are not associated with southern Chinese patients with Alzheimer's disease. Neurobiol Aging. 2014; 35(11):2656.e9-2656.e11. DOI: 10.1016/j.neurobiolaging.2014.05.015. View

13.

Song F, Poljak A, Crawford J, Kochan N, Wen W, Cameron B . Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals. PLoS One. 2012; 7(6):e34078. PMC: 3372509. DOI: 10.1371/journal.pone.0034078. View

14.

Gupta V, Doecke J, Hone E, Pedrini S, Laws S, Thambisetty M . Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimers Dement (Amst). 2016; 3:18-26. PMC: 4879652. DOI: 10.1016/j.dadm.2015.12.001. View

15.

Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y . Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry. 2010; 67(7):739-48. PMC: 3111021. DOI: 10.1001/archgenpsychiatry.2010.78. View

16.

Jongbloed W, Herrebout M, Blankenstein M, Veerhuis R . Quantification of clusterin in paired cerebrospinal fluid and plasma samples. Ann Clin Biochem. 2013; 51(Pt 5):557-67. DOI: 10.1177/0004563213503456. View

17.

Jongbloed W, van Dijk K, Mulder S, van de Berg W, Blankenstein M, van der Flier W . Clusterin Levels in Plasma Predict Cognitive Decline and Progression to Alzheimer's Disease. J Alzheimers Dis. 2015; 46(4):1103-10. DOI: 10.3233/JAD-150036. View

18.

Hesse C, Rosengren L, Fredman P, Davidsson P, Blennow K . Normal levels of clusterin in cerebrospinal fluid in Alzheimer's disease, and no change after acute ischemic stroke. J Alzheimers Dis. 2002; 3(5):435-442. DOI: 10.3233/jad-2001-3501. View

19.

Villemagne V, Burnham S, Bourgeat P, Brown B, Ellis K, Salvado O . Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study. Lancet Neurol. 2013; 12(4):357-67. DOI: 10.1016/S1474-4422(13)70044-9. View

20.

Lidstrom A, Bogdanovic N, Hesse C, Volkman I, Davidsson P, Blennow K . Clusterin (apolipoprotein J) protein levels are increased in hippocampus and in frontal cortex in Alzheimer's disease. Exp Neurol. 1999; 154(2):511-21. DOI: 10.1006/exnr.1998.6892. View