PET-MRI for the Study of Metabolic Bone Disease

Overview

Journal Curr Osteoporos Rep

Publisher Current Science

Specialties Endocrinology
Orthopedics

Date 2018 Oct 5

PMID 30284705

Citations 3

Authors

James S Yoder

Feliks Kogan

Garry E Gold

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: This review article attempts to summarize the current state and applications of the hybrid imaging modality of PET-MRI to metabolic bone diseases. The advances of PET and MRI are also discussed for metabolic bone diseases as potentially applied via PET-MRI.

Recent Findings: Etiologies and mechanisms of metabolic bone disease can be complex where molecular changes precede structural changes. Although PET-MRI has yet to be applied directly to metabolic bone disease, possible applications exist since PET, specifically F-NaF PET, can quantitatively track changes in bone metabolism and is useful for assessing treatment, while MRI can give detailed information on bone water concentration, porosity, and architecture through novel techniques such as UTE and ZTE MRI. Earlier detection and further understanding of metabolic bone disease via PET and MRI could lead to better treatment and prevention. More research using this modality is needed to further understand how it can be implemented in this realm.

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References

Huang B, Law M, Khong P . Whole-body PET/CT scanning: estimation of radiation dose and cancer risk. Radiology. 2009; 251(1):166-74. DOI: 10.1148/radiol.2511081300. View

Menendez M, Hettlich B, Wei L, Knopp M . Feasibility of NaF PET/CT and MRI for Noninvasive In Vivo Quantification of Knee Pathophysiological Bone Metabolism in a Canine Model of Post-traumatic Osteoarthritis. Mol Imaging. 2017; 16:1536012117714575. PMC: 5524230. DOI: 10.1177/1536012117714575. View

Patsch J, Li X, Baum T, Yap S, Karampinos D, Schwartz A . Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures. J Bone Miner Res. 2013; 28(8):1721-8. PMC: 3720702. DOI: 10.1002/jbmr.1950. View

Bala Y, Zebaze R, Ghasem-Zadeh A, Atkinson E, Iuliano S, Peterson J . Cortical porosity identifies women with osteopenia at increased risk for forearm fractures. J Bone Miner Res. 2014; 29(6):1356-62. PMC: 4156822. DOI: 10.1002/jbmr.2167. View

Chen K, Blebea J, Laredo J, Chen W, Alavi A, Torigian D . Evaluation of Musculoskeletal Disorders with PET, PET/CT, and PET/MR Imaging. PET Clin. 2016; 3(3):451-65. DOI: 10.1016/j.cpet.2009.03.003. View

Crymes Jr W, Demos H, Gordon L . Detection of musculoskeletal infection with 18F-FDG PET: review of the current literature. J Nucl Med Technol. 2004; 32(1):12-5. View

Kobayashi N, Inaba Y, Tateishi U, Yukizawa Y, Ike H, Inoue T . New application of 18F-fluoride PET for the detection of bone remodeling in early-stage osteoarthritis of the hip. Clin Nucl Med. 2013; 38(10):e379-83. DOI: 10.1097/RLU.0b013e31828d30c0. View

Agrawal K, Agarwal Y, Chopra R, Batra A, Chandra R, Thukral B . Evaluation of MR Spectroscopy and Diffusion-Weighted MRI in Postmenopausal Bone Strength. Cureus. 2015; 7(9):e327. PMC: 4627835. DOI: 10.7759/cureus.327. View

Chaudhry A, Gul M, Gould E, Teng M, Baker K, Matthews R . Utility of positron emission tomography-magnetic resonance imaging in musculoskeletal imaging. World J Radiol. 2016; 8(3):268-74. PMC: 4807335. DOI: 10.4329/wjr.v8.i3.268. View

10.

Wainwright S, Marshall L, Ensrud K, Cauley J, Black D, Hillier T . Hip fracture in women without osteoporosis. J Clin Endocrinol Metab. 2005; 90(5):2787-93. DOI: 10.1210/jc.2004-1568. View

11.

Ito M . Recent progress in bone imaging for osteoporosis research. J Bone Miner Metab. 2011; 29(2):131-40. DOI: 10.1007/s00774-010-0258-0. View

12.

Hirsch F, Sattler B, Sorge I, Kurch L, Viehweger A, Ritter L . PET/MR in children. Initial clinical experience in paediatric oncology using an integrated PET/MR scanner. Pediatr Radiol. 2013; 43(7):860-75. PMC: 3691480. DOI: 10.1007/s00247-012-2570-4. View

13.

Huovinen V, Saunavaara V, Kiviranta R, Tarkia M, Honka H, Stark C . Vertebral bone marrow glucose uptake is inversely associated with bone marrow fat in diabetic and healthy pigs: [(18)F]FDG-PET and MRI study. Bone. 2014; 61:33-8. DOI: 10.1016/j.bone.2013.12.022. View

14.

Kogan F, Fan A, Gold G . Potential of PET-MRI for imaging of non-oncologic musculoskeletal disease. Quant Imaging Med Surg. 2017; 6(6):756-771. PMC: 5219958. DOI: 10.21037/qims.2016.12.16. View

15.

Blake G, Siddique M, Frost M, Moore A, Fogelman I . Quantitative PET Imaging Using (18)F Sodium Fluoride in the Assessment of Metabolic Bone Diseases and the Monitoring of Their Response to Therapy. PET Clin. 2016; 7(3):275-91. DOI: 10.1016/j.cpet.2012.04.001. View

16.

Hawkins R, Choi Y, Huang S, Hoh C, Dahlbom M, Schiepers C . Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET. J Nucl Med. 1992; 33(5):633-42. View

17.

Blau M, Ganatra R, Bender M . 18 F-fluoride for bone imaging. Semin Nucl Med. 1972; 2(1):31-7. DOI: 10.1016/s0001-2998(72)80005-9. View

18.

Meunier P, Coindre J, Edouard C, Arlot M . Bone histomorphometry in Paget's disease. Quantitative and dynamic analysis of pagetic and nonpagetic bone tissue. Arthritis Rheum. 1980; 23(10):1095-103. DOI: 10.1002/art.1780231005. View

19.

Schwartz A, Sigurdsson S, Hue T, Lang T, Harris T, Rosen C . Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults. J Clin Endocrinol Metab. 2013; 98(6):2294-300. PMC: 3667265. DOI: 10.1210/jc.2012-3949. View

20.

Kogan F, Fan A, McWalter E, Oei E, Quon A, Gold G . PET/MRI of metabolic activity in osteoarthritis: A feasibility study. J Magn Reson Imaging. 2016; 45(6):1736-1745. PMC: 5761655. DOI: 10.1002/jmri.25529. View