Bioactive Lipids and Pathological Retinal Angiogenesis

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 2018 Oct 3

PMID 30276789

Citations 23

Authors

Khaled Elmasry

Ahmed S Ibrahim

Samer Abdulmoneim

Mohamed Al-Shabrawey

Affiliations

Soon will be listed here.

Abstract

Angiogenesis, disruption of the retinal barrier, leukocyte-adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis. Given the conflicting role of bioactive lipids reported in the current literature, the goal of this review is to provide the reader a clear road map of what has been accomplished so far in the field with specific focus on the role of polyunsaturated fatty acids (PUFAs)-derived metabolites in proliferative retinopathies. This necessarily entails a description of the different retina cells, blood retina barriers and the role of (PUFAs)-derived metabolites in diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration as the most common types of proliferative retinopathies.

Citing Articles

Müller cells and retinal angiogenesis: critical regulators in health and disease.

Medina-Arellano A, Albert-Garay J, Medina-Sanchez T, Fonseca K, Ruiz-Cruz M, Ochoa-de la Paz L Front Cell Neurosci. 2024; 18:1513686.

PMID: 39720707 PMC: 11666533. DOI: 10.3389/fncel.2024.1513686.

Possible Role of Endothelial-Derived Cellular and Exosomal-miRNAs in Lipid-Mediated Diabetic Retinopathy: Microarray Studies.

Elmasry K, Habib S, Helwa I, Khaled M, Ibrahim A, Tawfik A Cells. 2024; 13(22).

PMID: 39594634 PMC: 11592818. DOI: 10.3390/cells13221886.

Autosomal-dominant macular dystrophy linked to a chromosome 17 tandem duplication.

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The Association between Diabetic Retinopathy and Macular Degeneration: A Nationwide Population-Based Study.

Lin H, Zheng C, Tsai C, Chen C, Chou Y, Zheng J Biomedicines. 2024; 12(4).

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Andrographolide suppresses hypoxia-induced embryonic hyaloid vascular system development through HIF-1a/VEGFR2 signaling pathway.

Jin Z, Guo Q, Wang Z, Wu X, Hu W, Li J Front Cardiovasc Med. 2023; 10:1090938.

PMID: 36844722 PMC: 9944699. DOI: 10.3389/fcvm.2023.1090938.

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