Autocrine Growth of Human B Lymphocytes: Maintained Response to Autostimulatory Factors is the Special Feature of Immortalization by Epstein-Barr Virus--a Hypothesis

Overview

Journal Med Oncol Tumor Pharmacother

Specialties Oncology
Pharmacology

Date 1986 Jan 1

PMID 3027466

Citations 3

Authors

J Gordon

G Guy

L Walker

P Nathan

R Exley

M Clemens

Affiliations

Soon will be listed here.

Abstract

The autocrine growth profile of human B lymphocytes transformed with Epstein-Barr virus (EBV) was found to comprise three distinct components: a B-cell growth factor (BCGF); an interleukin-1 (IL-1)-like activity; an activity requiring cell-to-cell contact for its action. Observations on the inhibition of the EBV-carrying Daudi lymphoma line by alpha-interferon indicated that loss of response to these autostimulatory factors was underlying growth cessation. Furthermore, a putative receptor for BCGF was found to be down-regulated on B cells stimulated with non-transforming mitogens but constitutively expressed following EBV-transformation. Taken together with recent evidence that normal B cells produce autostimulatory factors, these findings suggest that the special feature of autocrine growth by EBV-immortalized cells is a maintenance of what should normally be a transient phenotype, possibly through deregulation of receptor expression. This hypothesis is discussed.

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