Comparison of Trans-fatty Acids on Proliferation and Migration of Vascular Smooth Muscle Cells

Overview

Journal Food Sci Biotechnol

Specialty Biotechnology

Date 2018 Sep 29

PMID 30263571

Citations 1

Authors

Haewon Kim

Chang Hee Jeong

Hong Gu Lee

Sung Gu Han

Affiliations

Soon will be listed here.

Abstract

Consumption of trans-fatty acids has been linked to an increased risk of cardiovascular diseases, such as atherosclerosis. Milk and dairy products contain trans-fatty acids, such as transvaccenic acid (TVA) and conjugated linoleic acid (CLA). Although artificially hydrogenated trans-fatty acids (e.g., elaidic acid (EA)) are known to induce atherosclerosis, it is unclear whether ruminant trans-fats, such as TVA, are associated with such diseases. Therefore, we investigated the effects of TVA on vascular smooth muscle cells (VSMCs). VSMCs were treated with TVA, CLA, and EA at 0-100 μM for 24 h. Cell proliferation and migration increased upon treatment with EA, not with TVA and CLA. EA increased protein expression of proliferation-associated proteins (cyclin-dependent kinase 4 (CDK4) and cyclin D1), while TVA and CLA decreased CDK4 expression. These results suggest that TVA is not as risky as other trans-fatty acids such as EA in the vascular system.

Citing Articles

The Effect of Trans Fatty Acids on Human Health: Regulation and Consumption Patterns.

Pipoyan D, Stepanyan S, Stepanyan S, Beglaryan M, Costantini L, Molinari R Foods. 2021; 10(10).

PMID: 34681504 PMC: 8535577. DOI: 10.3390/foods10102452.

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