Role of Genetic and Environmental Factors in DNA Methylation of Lipid Metabolism

Overview

Journal Genes Dis

Date 2018 Sep 28

PMID 30258929

Citations 7

Authors

Zhen He

Rong Zhang

Feng Jiang

Wenjing Hou

Cheng Hu

Affiliations

Soon will be listed here.

Abstract

A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism. DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate genetic variants and environmental factors into phenotypic traits. Therefore, elucidating the factors that underlie inter-individual DNA methylation variations gives us an opportunity to predict diseases and interfere with the establishment of aberrant DNA methylation early. In this review, we summarize the findings of DNA methylation-related studies focused on unravelling the potential role of genetic and environmental factors in DNA methylation and the regulatory effect of DNA methylation on gene expression in lipid metabolism.

Citing Articles

Multi-Omics Insights into Regulatory Mechanisms Underlying Differential Deposition of Intramuscular and Abdominal Fat in Chickens.

Xing Y, Ma C, Guan H, Shen J, Shen Y, Li G Biomolecules. 2025; 15(1).

PMID: 39858528 PMC: 11763713. DOI: 10.3390/biom15010134.

Impact of combined exercise on blood DNA methylation and physical health in older women with obesity.

Dawangpa A, Chitta P, da Silva Rodrigues G, Iadsee N, Noronha N, Nonino C PLoS One. 2024; 19(12):e0315250.

PMID: 39680552 PMC: 11649090. DOI: 10.1371/journal.pone.0315250.

Druggability of lipid metabolism modulation against renal fibrosis.

Chen Y, Chen X, Zhang S Acta Pharmacol Sin. 2021; 43(3):505-519.

PMID: 33990764 PMC: 8888625. DOI: 10.1038/s41401-021-00660-1.

Incorporation of DNA methylation into eQTL mapping in African Americans.

Singh A, Zhong Y, Nahlawi L, Park C, De T, Alarcon C Pac Symp Biocomput. 2021; 26:244-255.

PMID: 33691021 PMC: 7958994.

The many lives of Myc in the pancreatic β-cell.

Rosselot C, Baumel-Alterzon S, Li Y, Brill G, Lambertini L, Katz L J Biol Chem. 2020; 296:100122.

PMID: 33239359 PMC: 7949031. DOI: 10.1074/jbc.REV120.011149.

References

Crider K, Quinlivan E, Berry R, Hao L, Li Z, Maneval D . Genomic DNA methylation changes in response to folic acid supplementation in a population-based intervention study among women of reproductive age. PLoS One. 2011; 6(12):e28144. PMC: 3233549. DOI: 10.1371/journal.pone.0028144. View

Jjingo D, Conley A, Yi S, Lunyak V, Jordan I . On the presence and role of human gene-body DNA methylation. Oncotarget. 2012; 3(4):462-74. PMC: 3380580. DOI: 10.18632/oncotarget.497. View

Gillberg L, Perfilyev A, Brons C, Thomasen M, Grunnet L, Volkov P . Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding. Diabetologia. 2016; 59(4):799-812. DOI: 10.1007/s00125-015-3852-9. View

Robertson K . DNA methylation and human disease. Nat Rev Genet. 2005; 6(8):597-610. DOI: 10.1038/nrg1655. View

Jacobsen S, Brons C, Bork-Jensen J, Ribel-Madsen R, Yang B, Lara E . Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skeletal muscle of healthy young men. Diabetologia. 2012; 55(12):3341-9. DOI: 10.1007/s00125-012-2717-8. View

Brons C, Jacobsen S, Nilsson E, Ronn T, Jensen C, Storgaard H . Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner. J Clin Endocrinol Metab. 2010; 95(6):3048-56. DOI: 10.1210/jc.2009-2413. View

Perfilyev A, Dahlman I, Gillberg L, Rosqvist F, Iggman D, Volkov P . Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial. Am J Clin Nutr. 2017; 105(4):991-1000. DOI: 10.3945/ajcn.116.143164. View

Dogan M, Shields B, Cutrona C, Gao L, Gibbons F, Simons R . The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women. BMC Genomics. 2014; 15:151. PMC: 3936875. DOI: 10.1186/1471-2164-15-151. View

Wolff G, Kodell R, Moore S, Cooney C . Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J. 1998; 12(11):949-57. View

10.

Ma Y, Follis J, Smith C, Tanaka T, Manichaikul A, Chu A . Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Am J Clin Nutr. 2016; 103(2):567-78. PMC: 5260796. DOI: 10.3945/ajcn.115.112987. View

11.

Gibbs J, van der Brug M, Hernandez D, Traynor B, Nalls M, Lai S . Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet. 2010; 6(5):e1000952. PMC: 2869317. DOI: 10.1371/journal.pgen.1000952. View

12.

Laker R, Lillard T, Okutsu M, Zhang M, Hoehn K, Connelly J . Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes. 2014; 63(5):1605-11. PMC: 5860829. DOI: 10.2337/db13-1614. View

13.

Olsson A, Volkov P, Bacos K, Dayeh T, Hall E, Nilsson E . Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets. PLoS Genet. 2014; 10(11):e1004735. PMC: 4222689. DOI: 10.1371/journal.pgen.1004735. View

14.

Houde A, Legare C, Biron S, Lescelleur O, Biertho L, Marceau S . Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women. BMC Med Genet. 2015; 16:29. PMC: 4631085. DOI: 10.1186/s12881-015-0174-1. View

15.

do Amaral C, Milagro F, Curi R, Martinez J . DNA methylation pattern in overweight women under an energy-restricted diet supplemented with fish oil. Biomed Res Int. 2014; 2014:675021. PMC: 3919118. DOI: 10.1155/2014/675021. View

16.

Kerkel K, Spadola A, Yuan E, Kosek J, Jiang L, Hod E . Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet. 2008; 40(7):904-8. DOI: 10.1038/ng.174. View

17.

Barres R, Yan J, Egan B, Treebak J, Rasmussen M, Fritz T . Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 2012; 15(3):405-11. DOI: 10.1016/j.cmet.2012.01.001. View

18.

Guay S, Brisson D, Lamarche B, Marceau P, Vohl M, Gaudet D . DNA methylation variations at CETP and LPL gene promoter loci: new molecular biomarkers associated with blood lipid profile variability. Atherosclerosis. 2013; 228(2):413-20. DOI: 10.1016/j.atherosclerosis.2013.03.033. View

19.

Irvin M, Zhi D, Joehanes R, Mendelson M, Aslibekyan S, Claas S . Epigenome-wide association study of fasting blood lipids in the Genetics of Lipid-lowering Drugs and Diet Network study. Circulation. 2014; 130(7):565-72. PMC: 4209699. DOI: 10.1161/CIRCULATIONAHA.114.009158. View

20.

Grundberg E, Meduri E, Sandling J, Hedman A, Keildson S, Buil A . Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements. Am J Hum Genet. 2013; 93(5):876-90. PMC: 3824131. DOI: 10.1016/j.ajhg.2013.10.004. View