P120 Catenin Expression and Its Correlation with E-cadherin in Salivary Gland Neoplasms

Overview

Journal J Oral Biol Craniofac Res

Publisher Elsevier

Date 2018 Sep 28

PMID 30258767

Citations 4

Authors

Ekarat Phattarataratip

Nicha Kositkittiwanit

Pruch Kajornkiatkul

Pataraporn Yeunyong

Ratanatip Ratanapitak

Affiliations

Soon will be listed here.

Abstract

Objectives: Altered P120 catenin expression has been associated with E-cadherin loss and poor prognosis in several cancers. The objectives of this study were to examine the P120 catenin expression in salivary gland neoplasms in correlation with E-cadherin and assess the relationships between their expression levels and pathologic characteristics.

Methods: Fifty-two cases of salivary gland neoplasms, i.e. 25 mucoepidermoid carcinomas (MEC), 13 adenoid cystic carcinomas (ACC), 12 pleomorphic adenomas (PA) and 2 polymorphous adenocarcinomas (PAC) were included. The expression of P120 catenin and E-cadherin was investigated immunohistochemically.

Results: Both P120 catenin and E-cadherin were overexpressed in salivary gland neoplasms, compared to normal tissue. P120 catenin was primarily detected on the membrane of neoplastic cells in most cases. A significant correlation between levels of expression of both proteins was noted in MECs. In ACCs and PA, ductal cells showed positive immunoreactivity, whereas myoepithelial cells variably expressed both proteins. Increased P120 catenin expression was significantly associated with the solid subtype of ACCs.

Conclusions: The cadherin-catenin complex is preserved in the heterogenous tumor cell population in salivary gland neoplasms. Overexpression of P120 catenin may be involved in the progression to solid ACCs.

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References

Economopoulou P, Hanby A, Odell E . Expression of E-cadherin, cellular differentiation and polarity in epithelial salivary neoplasms. Oral Oncol. 2000; 36(6):515-8. DOI: 10.1016/s1368-8375(00)00043-9. View

Gheldof A, Berx G . Cadherins and epithelial-to-mesenchymal transition. Prog Mol Biol Transl Sci. 2013; 116:317-36. DOI: 10.1016/B978-0-12-394311-8.00014-5. View

Soto E, Yanagisawa M, Marlow L, Copland J, Perez E, Anastasiadis P . p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression. J Cell Biol. 2008; 183(4):737-49. PMC: 2582886. DOI: 10.1083/jcb.200805113. View

Prabhu S, Kaveri H, Rekha K . Benign, malignant salivary gland tumors: comparison of immunohistochemical expression of e-cadherin. Oral Oncol. 2008; 45(7):594-9. DOI: 10.1016/j.oraloncology.2008.08.004. View

Furuse C, Ramos Cury P, Altemani A, Santos Pinto Jr D, de Araujo N, de Araujo V . Beta-catenin and E-cadherin expression in salivary gland tumors. Int J Surg Pathol. 2006; 14(3):212-7. DOI: 10.1177/1066896906290652. View

Gul I, Hulpiau P, Saeys Y, van Roy F . Evolution and diversity of cadherins and catenins. Exp Cell Res. 2017; 358(1):3-9. DOI: 10.1016/j.yexcr.2017.03.001. View

Brandwein M, Ivanov K, Wallace D, Hille J, Wang B, Fahmy A . Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001; 25(7):835-45. DOI: 10.1097/00000478-200107000-00001. View

Chetty R, Jain D, Serra S . p120 catenin reduction and cytoplasmic relocalization leads to dysregulation of E-cadherin in solid pseudopapillary tumors of the pancreas. Am J Clin Pathol. 2008; 130(1):71-6. DOI: 10.1309/FEYD99TXC4LMYVA5. View

Schackmann R, Tenhagen M, van de Ven R, Derksen P . p120-catenin in cancer - mechanisms, models and opportunities for intervention. J Cell Sci. 2013; 126(Pt 16):3515-25. DOI: 10.1242/jcs.134411. View

10.

Sarrio D, Perez-Mies B, Hardisson D, Moreno-Bueno G, Suarez A, Cano A . Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. Oncogene. 2004; 23(19):3272-83. DOI: 10.1038/sj.onc.1207439. View

11.

Thoreson M, Reynolds A . Altered expression of the catenin p120 in human cancer: implications for tumor progression. Differentiation. 2002; 70(9-10):583-9. DOI: 10.1046/j.1432-0436.2002.700911.x. View

12.

Reynolds A, Roczniak-Ferguson A . Emerging roles for p120-catenin in cell adhesion and cancer. Oncogene. 2004; 23(48):7947-56. DOI: 10.1038/sj.onc.1208161. View

13.

Birchmeier W, Behrens J . Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta. 1994; 1198(1):11-26. DOI: 10.1016/0304-419x(94)90003-5. View

14.

Paredes J, Figueiredo J, Albergaria A, Oliveira P, Carvalho J, Ribeiro A . Epithelial E- and P-cadherins: role and clinical significance in cancer. Biochim Biophys Acta. 2012; 1826(2):297-311. DOI: 10.1016/j.bbcan.2012.05.002. View

15.

Silvera D, Arju R, Darvishian F, Levine P, Zolfaghari L, Goldberg J . Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer. Nat Cell Biol. 2009; 11(7):903-8. DOI: 10.1038/ncb1900. View

16.

Bellovin D, Bates R, Muzikansky A, Rimm D, Mercurio A . Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. Cancer Res. 2005; 65(23):10938-45. DOI: 10.1158/0008-5472.CAN-05-1947. View

17.

Anastasiadis P, Reynolds A . The p120 catenin family: complex roles in adhesion, signaling and cancer. J Cell Sci. 2000; 113 ( Pt 8):1319-34. DOI: 10.1242/jcs.113.8.1319. View

18.

Yanagisawa M, Huveldt D, Kreinest P, Lohse C, Cheville J, Parker A . A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease. J Biol Chem. 2008; 283(26):18344-54. PMC: 2440599. DOI: 10.1074/jbc.M801192200. View

19.

Johnson E, Seachrist D, DeLeon-Rodriguez C, Lozada K, Miedler J, Abdul-Karim F . HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42. J Biol Chem. 2010; 285(38):29491-501. PMC: 2937981. DOI: 10.1074/jbc.M110.136770. View

20.

Andreadis D, Epivatianos A, Mireas G, Nomikos A, Poulopoulos A, Yiotakis J . Immunohistochemical detection of E-cadherin in certain types of salivary gland tumours. J Laryngol Otol. 2006; 120(4):298-304. DOI: 10.1017/S0022215106000351. View