The Role of Interleukin-6-STAT3 Signalling in Glioblastoma

Overview

Journal Oncol Lett

Specialty Oncology

Date 2018 Sep 26

PMID 30250528

Citations 62

Authors

Alice J West

Vanessa Tsui

Stanley S Stylli

Hong P T Nguyen

Andrew P Morokoff

Andrew H Kaye

Rodney B Luwor

Affiliations

Soon will be listed here.

Abstract

Glioblastoma is the most common type of malignant brain tumor among adults and is currently a non-curable disease due primarily to its highly invasive phenotype, and the lack of successful current therapies. Despite surgical resection and post-surgical treatment patients ultimately develop recurrence of the tumour. Several signalling molecules have been implicated in the development, progression and aggressiveness of glioblastoma. The present study reviewed the role of interleukin (IL)-6, a cytokine known to be important in activating several pro-oncogenic signaling pathways in glioblastoma. The current study particularly focused on the contribution of IL-6 in recurrent glioblastoma, with particular focus on glioblastoma stem cells and resistance to therapy.

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