Interleukin-6 Gene Amplification and Shortened Survival in Glioblastoma Patients

Overview

Journal Br J Cancer

Specialty Oncology

Date 2007 Jan 17

PMID 17224923

Citations 62

Authors

A Tchirkov

T Khalil

E Chautard

K Mokhtari

L Veronese

B Irthum

P Vago

J-L Kemeny

P Verrelle

Affiliations

Soon will be listed here.

Abstract

Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence in situ hybridisation. Amplification events were detected only in glioblastomas (15 out of 36 cases), the most malignant tumours, and were significantly associated with decreased patient survival.

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