Effects of a Mu-opioid Receptor Agonist (codeine Phosphate) on Visuo-motor Coordination and Dynamic Visual Acuity in Man

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1986 Nov 1

PMID 3024689

Citations 9

Authors

C M Bradley

A N Nicholson

Affiliations

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Abstract

Effects of codeine (30, 60 and 90 mg) on visuo-motor coordination and dynamic visual acuity, together with critical flicker fusion, digit symbol substitution, complex reaction time and subjective assessments of mood, were studied from 0.75-2.0 h after ingestion by six healthy female adults. The study was double-blind and placebo controlled, and triprolidine (10 mg) was used as the active control. The effect on visuo-motor coordination was limited and was dose related and linear, and performance was altered on visuo-motor coordination with 60 and 90 mg codeine, and on dynamic visual acuity with 90 mg codeine (P less than 0.05). No other effect of codeine was detected. Modulated neuromuscular function is likely to be the common denominator of the changes in performance with codeine, though nausea, but not sedation, may be a contributory factor. It is possible that altered performance with codeine may involve interactions with different receptors than those which lead to sedation.

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References

KANTOR T, Sunshine A, LASKA E, Meisner M, Hopper M . Oral analgesic studies: pentazocine hydrochloride, codeine, aspirin, and placebo and their influence on response to placebo. Clin Pharmacol Ther. 1966; 7(4):447-54. DOI: 10.1002/cpt196674447. View

SIMONSON E, Brozek J . Flicker fusion frequency; background and applications. Physiol Rev. 1952; 32(3):349-78. DOI: 10.1152/physrev.1952.32.3.349. View

Cox B . A recessive lethal super-suppressor mutation in yeast and other psi phenomena. Heredity (Edinb). 1971; 26(2):211-32. DOI: 10.1038/hdy.1971.28. View

Keller E . Participation of medial pontine reticular formation in eye movement generation in monkey. J Neurophysiol. 1974; 37(2):316-32. DOI: 10.1152/jn.1974.37.2.316. View

WAIFE S, Gruber Jr C, Rodda B, Nash J . Problems and solutions to single-dose testing of analgesics: comparison of propoxyphene, codeine, and fenoprofen. Int J Clin Pharmacol Biopharm. 1975; 12(1-2):301-4. View

Pickworth W, SHARPE L . EEG-behavioral dissociation after morphine-and cyclazocine-like drugs in the dog: further evidence for two opiate receptors. Neuropharmacology. 1979; 18(7):617-22. DOI: 10.1016/0028-3908(79)90114-x. View

Nicholson A . Effect of the antihistamines, brompheniramine maleate and triprolidine hydrochloride, on performance in man. Br J Clin Pharmacol. 1979; 8(4):321-4. PMC: 1429839. DOI: 10.1111/j.1365-2125.1979.tb04712.x. View

Rothenberg S, Schottenfeld S, Gross K, Selkoe D . Specific oculomotor deficit after acute methadone. I. Saccadic eye movements. Psychopharmacology (Berl). 1980; 67(3):221-7. DOI: 10.1007/BF00431260. View

Rothenberg S, Schottenfeld S, Selkoe D, Gross K . Specific oculomotor deficit after acute methadone. II. Smooth pursuit eye movements. Psychopharmacology (Berl). 1980; 67(3):229-34. DOI: 10.1007/BF00431261. View

10.

KANTOR T, Hopper M, LASKA E . Adverse effects of commonly ordered oral narcotics. J Clin Pharmacol. 1981; 21(1):1-8. DOI: 10.1002/j.1552-4604.1981.tb01724.x. View

11.

Liljequist R . Codeine-induced memory changes: nature and relationship to opiate system. Eur J Clin Pharmacol. 1981; 20(2):99-107. DOI: 10.1007/BF00607144. View

12.

Nicholson A, Stone B . Hypnotic activity and effects on performance of lormetazepam and camazepam--analogues of temazepam. Br J Clin Pharmacol. 1982; 13(3):433-9. PMC: 1402107. DOI: 10.1111/j.1365-2125.1982.tb01398.x. View

13.

Redpath J, Pleuvry B . Double-blind comparison of the respiratory and sedative effects of codeine phosphate and (+/-)-glaucine phosphate in human volunteers. Br J Clin Pharmacol. 1982; 14(4):555-8. PMC: 1427601. DOI: 10.1111/j.1365-2125.1982.tb02028.x. View

14.

Nicholson A, Smith P, Spencer M . Antihistamines and visual function: studies on dynamic acuity and the pupillary response to light. Br J Clin Pharmacol. 1982; 14(5):683-90. PMC: 1427480. DOI: 10.1111/j.1365-2125.1982.tb04957.x. View

15.

Hayes A, Tyers M . Determination of receptors that mediate opiate side effects in the mouse. Br J Pharmacol. 1983; 79(3):731-6. PMC: 2044905. DOI: 10.1111/j.1476-5381.1983.tb10011.x. View

16.

Nicholson A, Stone B . The H1-antagonist mequitazine: studies on performance and visual function. Eur J Clin Pharmacol. 1983; 25(4):563-6. DOI: 10.1007/BF00542129. View

17.

Kantor T, Cavaliere M, Hopper M, Roepke S . A double-blind parallel comparison of ketoprofen, codeine, and placebo in patients with moderate to severe postpartum pain. J Clin Pharmacol. 1984; 24(5-6):228-34. DOI: 10.1002/j.1552-4604.1984.tb02778.x. View

18.

Borland R, Nicholson A . Visual motor co-ordination and dynamic visual acuity. Br J Clin Pharmacol. 1984; 18 Suppl 1:69S-72S. PMC: 1463351. DOI: 10.1111/j.1365-2125.1984.tb02583.x. View

19.

Griffiths A, Marshall R, Richens A . Saccadic eye movement analysis as a measure of drug effects on human psychomotor performance. Br J Clin Pharmacol. 1984; 18 Suppl 1:73S-82S. PMC: 1463359. DOI: 10.1111/j.1365-2125.1984.tb02584.x. View

20.

Jasinski D, Martin W, HOELDTKE R . Studies of the dependence-producing properties of GPA-1657, profadol, and propiram in man. Clin Pharmacol Ther. 1971; 12(4):613-49. DOI: 10.1002/cpt1971124613. View