Neuropilins Guide Preganglionic Sympathetic Axons and Chromaffin Cell Precursors to Establish the Adrenal Medulla

Overview

Journal Development

Specialty Biology

Date 2018 Sep 22

PMID 30237243

Citations 14

Authors

Rachael Lumb

Mathew Tata

Xiangjun Xu

Andrew Joyce

Ceilidh Marchant

Natasha Harvey

Christiana Ruhrberg

Quenten Schwarz

Affiliations

Soon will be listed here.

Abstract

The adrenal medulla is composed of neuroendocrine chromaffin cells that secrete adrenaline into the systemic circulation to maintain physiological homeostasis and enable the autonomic stress response. How chromaffin cell precursors colonise the adrenal medulla and how they become connected to central nervous system-derived preganglionic sympathetic neurons remain largely unknown. By combining lineage tracing, gene expression studies, genetic ablation and the analysis of mouse mutants, we demonstrate that preganglionic axons direct chromaffin cell precursors into the adrenal primordia. We further show that preganglionic axons and chromaffin cell precursors require class 3 semaphorin (SEMA3) signalling through neuropilins (NRP) to target the adrenal medulla. Thus, SEMA3 proteins serve as guidance cues to control formation of the adrenal neuroendocrine system by establishing appropriate connections between preganglionic neurons and adrenal chromaffin cells that regulate the autonomic stress response.

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