Development of the Autonomic Nervous System: Clinical Implications

Overview

Journal Semin Neurol

Specialty Neurology

Date 2020 Sep 14

PMID 32927484

Citations 4

Authors

Frances Lefcort

Affiliations

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Abstract

Investigations of the cellular and molecular mechanisms that mediate the development of the autonomic nervous system have identified critical genes and signaling pathways that, when disrupted, cause disorders of the autonomic nervous system. This review summarizes our current understanding of how the autonomic nervous system emerges from the organized spatial and temporal patterning of precursor cell migration, proliferation, communication, and differentiation, and discusses potential clinical implications for developmental disorders of the autonomic nervous system, including familial dysautonomia, Hirschsprung disease, Rett syndrome, and congenital central hypoventilation syndrome.

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