Advances in Synthesis of Biotin and Assembly of Lipoic Acid

Overview

Journal Curr Opin Chem Biol

Publisher Elsevier

Specialty Biochemistry

Date 2018 Sep 22

PMID 30236800

Citations 16

Authors

John E Cronan

Affiliations

Soon will be listed here.

Abstract

Although biotin and lipoic acid are two universally conserved cofactors essential for intermediary metabolism, their synthetic pathways have become known only in recent years. Both pathways have unusual features. Biotin synthesis in Escherichia coli requires a methylation that is later removed whereas lipoic acid is assembled on the enzymes where it is required for activity by two different pathways.

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