A Single-step Sizing and Radiofrequency Ablation Catheter for Circumferential Ablation of Barrett's Esophagus: Results of a Pilot Study

Overview

Journal United European Gastroenterol J

Publisher Wiley

Specialty Gastroenterology

Date 2018 Sep 20

PMID 30228886

Citations 6

Authors

K Belghazi

R E Pouw

Cmt Sondermeijer

S L Meijer

E J Schoon

A D Koch

Blam Weusten

Jjghm Bergman

Affiliations

Soon will be listed here.

Abstract

Background: The 360 Express balloon catheter (360 Express) has the ability to self-adjust to the esophageal lumen, ensuring optimal tissue contact.

Objective: The objective of this article is to evaluate the efficacy and safety of the 360 Express for radiofrequency ablation (RFA) treatment of Barrett's esophagus (BE).

Methods: BE patients with low-grade dysplasia (LGD), high-grade dysplasia (HGD) or early cancer (EC) were included. Visible lesions were removed by endoscopic resection (ER) prior to RFA. RFA was performed with the 360 Express using the standard ablation regimen (12J/cm-clean-12J/cm). Primary outcome: BE regression percentage at three months. Secondary outcomes: procedure time, adverse events, complete eradication of dysplasia (CE-D) and intestinal metaplasia (CE-IM).

Results: Thirty patients (median BE C4M6) were included. Eight patients underwent ER prior to RFA. Median BE regression: 90%. Median procedure time: 31 minutes. Adverse events (13%): laceration ( = 1); atrial fibrillation ( = 1); vomiting and dysphagia ( = 1); dysregulated diabetes ( = 1). After subsequent treatment CE-D and CE-IM was achieved in 97% and 87%, respectively. In 10% a stenosis developed during additional treatment requiring a median of one dilation.

Conclusion: This study shows that circumferential RFA using the 360 Express may shorten procedure time, while maintaining efficacy compared to standard circumferential RFA.

Citing Articles

Atrial Flutter After Radiofrequency Ablation for Barrett's Esophagus: A Case Report.

Fassari A, De Blasi V, Basile M, Perretta S Am J Case Rep. 2023; 24:e941264.

PMID: 37794654 PMC: 10565709. DOI: 10.12659/AJCR.941264.

What Is "Cold" and What Is "Hot" in Mucosal Ablation for Barrett's Oesophagus-Related Dysplasia: A Practical Guide.

Spadaccini M, Alfarone L, Chandrasekar V, Maselli R, Capogreco A, Franchellucci G Life (Basel). 2023; 13(4).

PMID: 37109552 PMC: 10142767. DOI: 10.3390/life13041023.

Clinical adverse events and device failures for the Barrx™ radiofrequency ablation catheter system: a MAUDE database analysis.

Dubrouskaya K, Hagenstein L, Ramai D, Adler D Ann Gastroenterol. 2022; 35(4):345-350.

PMID: 35784622 PMC: 9210780. DOI: 10.20524/aog.2022.0721.

The role of ablation in the treatment of dysplastic Barrett's esophagus.

Sullivan R, Mulki R, Peter S Ther Adv Gastrointest Endosc. 2021; 14:26317745211049967.

PMID: 34708203 PMC: 8544766. DOI: 10.1177/26317745211049967.

Radiofrequency ablation for Barrett's oesophagus related neoplasia with the 360 Express catheter: initial experience from the United Kingdom and Ireland-preliminary results.

Magee C, Graham D, Gordon C, Dunn J, Penman I, Willert R Surg Endosc. 2021; 36(1):598-606.

PMID: 33547491 PMC: 8741663. DOI: 10.1007/s00464-021-08325-0.

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