Spontaneous Lymphocyte Transformation in Chronic Lymphocytic Leukaemia

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1977 Jun 1

PMID 302167

Citations 3

Authors

G Semenzato

G Amadori

F Tosato

G Gasparotto

Affiliations

Soon will be listed here.

Abstract

In ten patients with CLL and in eight controls T lymphocytes were separated out by the rosetting method. The in vitro reactivity of these cells and of unseparated lymphocytes was studied in cultures without stimulants. A net increase of spontaneous lymphocyte transformation was found in the populations enriched with T cells in patients with CLL with respect to analogous populations in the controls. This increase is interpreted as a cell-mediated immunological reaction and due to T-cell sensitization towards the neoplastic B cells.

Citing Articles

alpha-Mercaptopropionyl-glycine influence on the in vitro proliferative response of human lymphocytes.

Semenzato G, Pezzutto A, Amadori G, Raimondi R, Gasparotto G Experientia. 1979; 35(8):1109-10.

PMID: 477897 DOI: 10.1007/BF01949972.

Immunobiology of paediatric intracranial tumours. A preliminary report.

Gerosa M, Amadori G, Semenzato C, Raumer R, Cisotto P, Pezzuto A Acta Neurochir (Wien). 1979; 50(1-2):49-54.

PMID: 316267 DOI: 10.1007/BF01813548.

Active E rosette formation by human lymphoblasts.

Semenzato G, Amadori G, SARASIN P, Gasparotto G Immunology. 1978; 34(4):721-4.

PMID: 309851 PMC: 1457165.

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