Probiotics in the Treatment of Colorectal Cancer

Overview

Journal Medicines (Basel)

Specialty Pharmacology

Date 2018 Sep 13

PMID 30205429

Citations 30

Authors

Robert Hendler

Yue Zhang

Affiliations

Soon will be listed here.

Abstract

The human microbiome plays many roles in inflammation, drug metabolism, and even the development of cancer that we are only beginning to understand. Colorectal cancer has been a focus for study in this field as its pathogenesis and its response to treatment have both been linked to the functioning of microbiota. This literature review evaluates the animal and human studies that have explored this relationship. By manipulating the microbiome with interventions such as probiotic administration, we may be able to reduce colorectal cancer risk and improve the safety and effectiveness of cancer therapy even though additional clinical research is still necessary.

Citing Articles

Probiotic Mixture Attenuates Colorectal Tumorigenesis in Murine AOM/DSS Model by Suppressing STAT3, Inducing Apoptotic p53 and Modulating Gut Microbiota.

Leung H, Lo E, Chen C, Zhang F, Felicianna , Ismaiah M Probiotics Antimicrob Proteins. 2024; .

PMID: 39641861 DOI: 10.1007/s12602-024-10405-1.

Role of Native Probiotic Lactobacillus Species via TGF-β Signaling Pathway Modulation in CRC.

Sepehr A, Aghamohammad S, Ghanavati R, Talebi M, Pourshafie M, Rohani M Iran Biomed J. 2024; 28(4):168-78.

PMID: 39279541 PMC: 11444483. DOI: 10.61186/ibj.4012.

Prevalence and influencing factors of probiotic usage among colorectal cancer patients in China: A national database study.

Yao D, He W, Hu Y, Yuan Y, Xu H, Wang J PLoS One. 2023; 18(9):e0291864.

PMID: 37733795 PMC: 10513277. DOI: 10.1371/journal.pone.0291864.

Diet-gut microbial interactions influence cancer immunotherapy.

Wang X, Geng S Front Oncol. 2023; 13:1138362.

PMID: 37035188 PMC: 10081683. DOI: 10.3389/fonc.2023.1138362.

Ameliorates Colorectal Tumorigenesis and Suppresses Proliferation of HCT116 Colorectal Cancer Cells.

Dikeocha I, Al-Kabsi A, Chiu H, Alshawsh M Biomedicines. 2022; 10(5).

PMID: 35625865 PMC: 9138996. DOI: 10.3390/biomedicines10051128.

References

An J, Ha E . Combination Therapy of Lactobacillus plantarum Supernatant and 5-Fluouracil Increases Chemosensitivity in Colorectal Cancer Cells. J Microbiol Biotechnol. 2016; 26(8):1490-503. DOI: 10.4014/jmb.1605.05024. View

Raskov H, Burcharth J, Pommergaard H . Linking Gut Microbiota to Colorectal Cancer. J Cancer. 2017; 8(17):3378-3395. PMC: 5687151. DOI: 10.7150/jca.20497. View

Bowen J, Stringer A, Gibson R, Yeoh A, Hannam S, Keefe D . VSL#3 probiotic treatment reduces chemotherapy-induced diarrhea and weight loss. Cancer Biol Ther. 2007; 6(9):1449-54. DOI: 10.4161/cbt.6.9.4622. View

Klampfer L . Cytokines, inflammation and colon cancer. Curr Cancer Drug Targets. 2011; 11(4):451-64. PMC: 3540985. DOI: 10.2174/156800911795538066. View

Krebs B . Prebiotic and Synbiotic Treatment before Colorectal Surgery--Randomised Double Blind Trial. Coll Antropol. 2016; 40(1):35-40. View

Zackular J, Baxter N, Iverson K, Sadler W, Petrosino J, Chen G . The gut microbiome modulates colon tumorigenesis. mBio. 2013; 4(6):e00692-13. PMC: 3892781. DOI: 10.1128/mBio.00692-13. View

Vetizou M, Pitt J, Daillere R, Lepage P, Waldschmitt N, Flament C . Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 2015; 350(6264):1079-84. PMC: 4721659. DOI: 10.1126/science.aad1329. View

Wu S, Rhee K, Albesiano E, Rabizadeh S, Wu X, Yen H . A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. 2009; 15(9):1016-22. PMC: 3034219. DOI: 10.1038/nm.2015. View

Dimidi E, Christodoulides S, Fragkos K, Scott S, Whelan K . The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2014; 100(4):1075-84. DOI: 10.3945/ajcn.114.089151. View

10.

Van Niel C, Feudtner C, Garrison M, Christakis D . Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis. Pediatrics. 2002; 109(4):678-84. DOI: 10.1542/peds.109.4.678. View

11.

Fuccio L, Guido A, Eusebi L, Laterza L, Grilli D, Cennamo V . Effects of probiotics for the prevention and treatment of radiation-induced diarrhea. J Clin Gastroenterol. 2009; 43(6):506-13. DOI: 10.1097/MCG.0b013e3181a1f59c. View

12.

Ericsson A, Akter S, Hanson M, Busi S, Parker T, Schehr R . Differential susceptibility to colorectal cancer due to naturally occurring gut microbiota. Oncotarget. 2015; 6(32):33689-704. PMC: 4741795. DOI: 10.18632/oncotarget.5604. View

13.

Tareb R, Bernardeau M, Gueguen M, Vernoux J . In vitro characterization of aggregation and adhesion properties of viable and heat-killed forms of two probiotic Lactobacillus strains and interaction with foodborne zoonotic bacteria, especially Campylobacter jejuni. J Med Microbiol. 2013; 62(Pt 4):637-649. DOI: 10.1099/jmm.0.049965-0. View

14.

Castellarin M, Warren R, Freeman J, Dreolini L, Krzywinski M, Strauss J . Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2011; 22(2):299-306. PMC: 3266037. DOI: 10.1101/gr.126516.111. View

15.

Shang F, Liu H . and colorectal cancer: A review. World J Gastrointest Oncol. 2018; 10(3):71-81. PMC: 5852398. DOI: 10.4251/wjgo.v10.i3.71. View

16.

Packey C, Ciorba M . Microbial influences on the small intestinal response to radiation injury. Curr Opin Gastroenterol. 2009; 26(2):88-94. PMC: 4063200. DOI: 10.1097/MOG.0b013e3283361927. View

17.

Qin J, Li R, Raes J, Arumugam M, Burgdorf K, Manichanh C . A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010; 464(7285):59-65. PMC: 3779803. DOI: 10.1038/nature08821. View

18.

Pala V, Sieri S, Berrino F, Vineis P, Sacerdote C, Palli D . Yogurt consumption and risk of colorectal cancer in the Italian European prospective investigation into cancer and nutrition cohort. Int J Cancer. 2011; 129(11):2712-9. DOI: 10.1002/ijc.26193. View

19.

Vanderpool C, Yan F, Polk D . Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases. Inflamm Bowel Dis. 2008; 14(11):1585-96. DOI: 10.1002/ibd.20525. View

20.

Chong E . A potential role of probiotics in colorectal cancer prevention: review of possible mechanisms of action. World J Microbiol Biotechnol. 2013; 30(2):351-74. DOI: 10.1007/s11274-013-1499-6. View