Progenitor Targeting by Adult Stem Cells in Ciona Homeostasis, Injury, and Regeneration

Overview

Journal Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2018 Sep 12

PMID 30205080

Citations 10

Authors

William R Jeffery

Affiliations

Soon will be listed here.

Abstract

In the ascidian Ciona intestinalis, oral siphon amputation activates adult stem cell niches in the branchial sac to divide and dispatch migratory progenitor cells to a regeneration blastema at the site of injury. This study shows that progenitor cells derived from branchial sac stem cell niches have roles in homeostasis, wound repair, and regeneration of the siphons and neural complex (NC). During homeostasis, progenitor cells targeted the pharyngeal stigmata to replace ciliated cells involved in filter feeding. After individual or double siphon amputations, progenitor cells specifically targeted the oral or atrial siphons or both siphons, and were involved in the replacement of siphon circular muscle fibers. After oral siphon wounding, progenitor cells targeted the wound sites, and in some cases a supernumerary siphon was formed, although progenitor cell targeting did not predict the induction of supernumerary siphons. Following NC ablation, progenitor cells specifically targeted the regenerating NC, and supplied the precursors of new brain and neural gland cells. The tissues and organs targeted by branchial sac stem cells exhibited apoptosis during homeostasis and injury. It is concluded that branchial sac progenitor cells are multipotent and show targeting specificity that is correlated with apoptosis during homeostatic growth, tissue repair, and regeneration.

Citing Articles

Differentially expressed chaperone genes reveal a stress response required for unidirectional regeneration in the basal chordate Ciona.

Jeffery W, Li B, Ng M, Li L, Goricki S, Ma L BMC Biol. 2023; 21(1):148.

PMID: 37365564 PMC: 10294541. DOI: 10.1186/s12915-023-01633-y.

Stemness Activity Underlying Whole Brain Regeneration in a Basal Chordate.

Gordon T, Zaquin T, Kowarsky M, Voskoboynik Y, Hendin N, Wurtzel O Cells. 2022; 11(23).

PMID: 36496987 PMC: 9738451. DOI: 10.3390/cells11233727.

Articulating the "stem cell niche" paradigm through the lens of non-model aquatic invertebrates.

Martinez P, Ballarin L, Ereskovsky A, Gazave E, Hobmayer B, Manni L BMC Biol. 2022; 20(1):23.

PMID: 35057814 PMC: 8781081. DOI: 10.1186/s12915-022-01230-5.

A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.

Rinkevich B, Ballarin L, Martinez P, Somorjai I, Ben-Hamo O, Borisenko I Biol Rev Camb Philos Soc. 2021; 97(1):299-325.

PMID: 34617397 PMC: 9292022. DOI: 10.1111/brv.12801.

Comparative transcriptomic analysis reveals gene regulation mediated by caspase activity in a chordate organism.

Krasovec G, Karaiskou A, Queinnec E, Chambon J BMC Mol Cell Biol. 2021; 22(1):51.

PMID: 34615460 PMC: 8495957. DOI: 10.1186/s12860-021-00388-0.

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