The Tunicate : A Model System for Understanding the Relationship Between Regeneration and Aging

The use of the tunicate as a model system to study the relationship between regeneration and aging is reviewed. has powerful regeneration capacities, which fade with age. Some additional benefits are-, a relatively short life span, the ability to study regeneration , the close phylogenetic relationship between tunicates and vertebrates, and the host of molecular tools already established in this system. The neural complex (NC), the oral siphon (OS), and the oral siphon pigment organs (OPO) have high capacities for regeneration. However, these organs show an inverse relationship between rate of regeneration and age. The ability to regenerate a complete OS disappears in the oldest animals of a natural population, probably due to the inability to form a blastema at the wound site. Effects on blastema formation could also be involved in the reduction of NC regeneration capacity. The fidelity of OPO restoration is also compromised by excess differentiation of precursor cells in local siphon niches in the oldest animals. The model provides a pathway to understand the molecular basis of these phenomena.