Increased Sensitivity to Alpha-adrenoceptor Stimulation but Intact Purinergic and Muscarinergic Effects in Prehypertensive Cardiac Hypertrophy of Spontaneously Hypertensive Rats

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1986 Jul 1

PMID 3020440

Citations 2

Authors

M Bohm

U Mende

W Schmitz

H Scholz

Affiliations

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Abstract

The effects of phenylephrine, isoprenaline and adenosine, (-)-N6-phenylisopropyladenosine (PIA) or carbachol alone and in the presence of isoprenaline on force of contraction were studied in isolated electrically driven papillary muscles of spontaneously hypertensive rats (SHR) and age-matched Wistar control rats. In SHR an increased heart to body weight ratio was observed when blood pressure was not yet elevated. During this stage of the syndrome (i.e. between the 27th and 35th day of life) phenylephrine was about 3.4 times more potent to increase force of contraction in SHR (mean EC50: 2.8 mumol l-1) than in control rats (mean EC50: 9.4 mumol l-1). The positive inotropic effect of isoprenaline was similar in SHR and control rats. Also no difference could be detected in the isoprenaline-antagonistic effect of adenosine, the adenosine receptor agonist PIA or carbachol. We conclude that an increased sensitivity to cardiac alpha-adrenoceptor stimulation might be related to prehypertensive cardiac hypertrophy in SHR.

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References

Simpson P . Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response. J Clin Invest. 1983; 72(2):732-8. PMC: 1129233. DOI: 10.1172/JCI111023. View

Bohm M, Bruckner R, Hackbarth I, Haubitz B, Linhart R, Meyer W . Adenosine inhibition of catecholamine-induced increase in force of contraction in guinea-pig atrial and ventricular heart preparations. Evidence against a cyclic AMP- and cyclic GMP-dependent effect. J Pharmacol Exp Ther. 1984; 230(2):483-92. View

Sen S, TARAZI R, Khairallah P, BUMPUS F . Cardiac hypertrophy in spontaneously hypertensive rats. Circ Res. 1974; 35(5):775-81. DOI: 10.1161/01.res.35.5.775. View

Sen S, TARAZI R, BUMPUS F . Cardiac hypertrophy and antihypertensive therapy. Cardiovasc Res. 1977; 11(5):427-33. DOI: 10.1093/cvr/11.5.427. View

Womble J, Haddox M, Russell D . Epinephrine elevation in plasma parallels canine cardiac hypertrophy. Life Sci. 1978; 23(19):1951-7. DOI: 10.1016/0024-3205(78)90562-3. View

Pfeffer M, Pfeffer J, WEISS A, Frohlich E . Development of SHR hypertension and cardiac hypertrophy during prolonged beta blockade. Am J Physiol. 1977; 232(6):H639-644. DOI: 10.1152/ajpheart.1977.232.6.H639. View

Motz W, Strauer B . Regression of cardiac hypertrophy after therapy in animal hypertension. J Cardiovasc Pharmacol. 1985; 7 Suppl 2:S56-61. DOI: 10.1097/00005344-198507002-00012. View

Pfeffer M, Pfeffer J . Pharmacologic regression of cardiac hypertrophy in experimental hypertension. J Cardiovasc Pharmacol. 1984; 6 Suppl 6:S865-9. View

CUTILLETTA A, Erinoff L, Heller A, Low J, Oparil S . Development of left ventricular hypertrophy in young spontaneously hypertensive rats after peripheral sympathectomy. Circ Res. 1977; 40(4):428-34. DOI: 10.1161/01.res.40.4.428. View

10.

Schrader J, Baumann G, Gerlach E . Adenosine as inhibitor of myocardial effects of catecholamines. Pflugers Arch. 1977; 372(1):29-35. DOI: 10.1007/BF00582203. View

11.

Limas C . Increased number of beta-adrenergic receptors in the hypertrophied myocardium. Biochim Biophys Acta. 1979; 588(1):174-8. DOI: 10.1016/0304-4165(79)90382-9. View

12.

Yamada S, Ishima T, Tomita T, Hayashi M, Okada T, Hayashi E . Alterations in cardiac alpha and beta adrenoceptors during the development of spontaneous hypertension. J Pharmacol Exp Ther. 1984; 228(2):454-60. View

13.

Bohm M, Meyer W, Mugge A, Schmitz W, Scholz H . Functional evidence for the existence of adenosine receptors in the human heart. Eur J Pharmacol. 1985; 116(3):323-6. DOI: 10.1016/0014-2999(85)90170-0. View

14.

Laks M, Morady F . Norepinephrine--the myocardial hypertrophy hormone?. Am Heart J. 1976; 91(5):674-5. DOI: 10.1016/s0002-8703(76)80156-1. View

15.

Watt A . Hypertrophic cardiomyopathy: a disease of impaired adenosine-mediated autoregulation of the heart. Lancet. 1984; 1(8389):1271-3. DOI: 10.1016/s0140-6736(84)92449-8. View

16.

Frohlich E, TARAZI R . Is arterial pressure the sole factor responsible for hypertensive cardiac hypertrophy?. Am J Cardiol. 1979; 44(5):959-63. DOI: 10.1016/0002-9149(79)90229-7. View

17.

Rossi M, Carillo S . Does norepinephrine play a central causative role in the process of cardiac hypertrophy?. Am Heart J. 1985; 109(3 Pt 1):622-4. DOI: 10.1016/0002-8703(85)90582-4. View

18.

Baumann G, Schrader J, Gerlach E . Inhibitory action of adenosine on histamine- and dopamine-stimulated cardiac contractility and adenylate cyclase in guinea pigs. Circ Res. 1981; 48(2):259-66. DOI: 10.1161/01.res.48.2.259. View

19.

Dobson Jr J . Mechanism of adenosine inhibition of catecholamine-induced responses in heart. Circ Res. 1983; 52(2):151-60. DOI: 10.1161/01.res.52.2.151. View

20.

Laks M, Morady F, Swan H . Myocardial hypertrophy produced by chronic infusion of subhypertensive doses of norepinephrine in the dog. Chest. 1973; 64(1):75-8. DOI: 10.1378/chest.64.1.75. View