Functional Evidence for the Existence of Adenosine Receptors in the Human Heart

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1985 Oct 22

PMID 3000800

Citations 16

Authors

M Bohm

W Meyer

A Mugge

W Schmitz

H Scholz

Affiliations

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Abstract

Adenosine added to isolated electrically driven preparations of human ventricular heart muscle antagonized the positive inotropic effect of isoprenaline (mean EC50 19 mumol 1(-1), n = 9). Similar effects were observed with the adenosine receptor agonist (-)-N6-phenylisopropyladenosine (mean EC50 0.5 mumol 1(-1), n = 7). These data provide functional evidence for the existence of adenosine receptors in the human myocardium which may modulate the force of contraction during beta-adrenergic stimulation and thus could be involved in the autoregulation of myocardial contractility.

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On inotropic effects of UTP in the human heart.

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A positive inotropic effect of adenosine in cardiac preparations of right atria from diseased human hearts.

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Pertussis toxin sensitive and insensitive effects of adenosine and carbachol in murine atria overexpressing A(1)-adenosine receptors.

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