Mechanisms of MicroRNA-mediated Gene Regulation in Unicellular Model Alga

Overview

Journal Biotechnol Biofuels

Publisher Biomed Central

Specialty Biotechnology

Date 2018 Sep 12

PMID 30202439

Citations 13

Authors

Sulin Lou

Ting Sun

Hui Li

Zhangli Hu

Affiliations

Soon will be listed here.

Abstract

MicroRNAs are a class of endogenous non-coding RNAs that play a vital role in post-transcriptional gene regulation in eukaryotic cells. In plants and animals, miRNAs are implicated in diverse roles ranging from immunity against viral infections, developmental pathways, molecular pathology of cancer and regulation of protein expression. However, the role of miRNAs in the unicellular model green alga remains unclear. The mode of action of miRNA-induced gene silencing in is very similar to that of higher eukaryotes, in terms of the activation of the RNA-induced silencing complex and mRNA targeting. Certain studies indicate that destabilization of mRNAs and mRNA turnover could be the major possible functions of miRNAs in eukaryotic algae. Here, we summarize recent findings that have advanced our understanding of miRNA regulatory mechanisms in .

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