OpenWorm: Overview and Recent Advances in Integrative Biological Simulation of

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2018 Sep 12

PMID 30201845

Citations 26

Authors

Gopal P Sarma

Chee Wai Lee

Tom Portegys

Vahid Ghayoomie

Travis Jacobs

Bradly Alicea

Matteo Cantarelli

Michael Currie

Richard C Gerkin

Shane Gingell

Padraig Gleeson

Richard Gordon

Ramin M Hasani

Giovanni Idili

Sergey Khayrulin

David Lung

Andrey Palyanov

Mark Watts

Stephen D Larson

Affiliations

Soon will be listed here.

Abstract

The adoption of powerful software tools and computational methods from the software industry by the scientific research community has resulted in a renewed interest in integrative, large-scale biological simulations. These typically involve the development of computational platforms to combine diverse, process-specific models into a coherent whole. The OpenWorm Foundation is an independent research organization working towards an integrative simulation of the nematode , with the aim of providing a powerful new tool to understand how the organism's behaviour arises from its fundamental biology. In this perspective, we give an overview of the history and philosophy of OpenWorm, descriptions of the constituent sub-projects and corresponding open-science management practices, and discuss current achievements of the project and future directions.This article is part of a discussion meeting issue 'Connectome to behaviour: modelling at cellular resolution'.

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