Role of Vitamin A in the Immune System

Overview

Journal J Clin Med

Specialty General Medicine

Date 2018 Sep 12

PMID 30200565

Citations 193

Authors

Zhiyi Huang

Yu Liu

Guangying Qi

David Brand

Song Guo Zheng

Affiliations

Soon will be listed here.

Abstract

Vitamin A (VitA) is a micronutrient that is crucial for maintaining vision, promoting growth and development, and protecting epithelium and mucus integrity in the body. VitA is known as an anti-inflammation vitamin because of its critical role in enhancing immune function. VitA is involved in the development of the immune system and plays regulatory roles in cellular immune responses and humoral immune processes. VitA has demonstrated a therapeutic effect in the treatment of various infectious diseases. To better understand the relationship between nutrition and the immune system, the authors review recent literature about VitA in immunity research and briefly introduce the clinical application of VitA in the treatment of several infectious diseases.

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References

Pino-Lagos K, Guo Y, Noelle R . Retinoic acid: a key player in immunity. Biofactors. 2010; 36(6):430-6. PMC: 3826167. DOI: 10.1002/biof.117. View

Scott C, Aumeunier A, Mowat A . Intestinal CD103+ dendritic cells: master regulators of tolerance?. Trends Immunol. 2011; 32(9):412-9. DOI: 10.1016/j.it.2011.06.003. View

Rytter M, Kolte L, Briend A, Friis H, Christensen V . The immune system in children with malnutrition--a systematic review. PLoS One. 2014; 9(8):e105017. PMC: 4143239. DOI: 10.1371/journal.pone.0105017. View

Beckett B, Chiba H, Chithalen J, Jones G, Metzger D, Chambon P . Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha. J Biol Chem. 1998; 273(4):2409-15. DOI: 10.1074/jbc.273.4.2409. View

Soprano K, Soprano D . Retinoic acid receptors and cancer. J Nutr. 2002; 132(12):3809S-3813S. DOI: 10.1093/jn/132.12.3809S. View

Drain P, Kupka R, Mugusi F, Fawzi W . Micronutrients in HIV-positive persons receiving highly active antiretroviral therapy. Am J Clin Nutr. 2007; 85(2):333-45. DOI: 10.1093/ajcn/85.2.333. View

Lippe B, Hensen L, Mendoza G, Finerman M, Welch M . Chronic vitamin A intoxication. A multisystem disease that could reach epidemic proportions. Am J Dis Child. 1981; 135(7):634-6. DOI: 10.1001/archpedi.1981.02130310040014. View

Xiao S, Jin H, Korn T, Liu S, Oukka M, Lim B . Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J Immunol. 2008; 181(4):2277-84. PMC: 2722959. DOI: 10.4049/jimmunol.181.4.2277. View

Bastien J, Rochette-Egly C . Nuclear retinoid receptors and the transcription of retinoid-target genes. Gene. 2004; 328:1-16. DOI: 10.1016/j.gene.2003.12.005. View

10.

Hiemstra I, Beijer M, Veninga H, Vrijland K, Borg E, Olivier B . The identification and developmental requirements of colonic CD169⁺ macrophages. Immunology. 2014; 142(2):269-78. PMC: 4008234. DOI: 10.1111/imm.12251. View

11.

Tao X, Ma J, Zhang Y, Yu J, Cai L, Wang J . Neutralization of IL-4 and IFN-γ Facilitates inducing TGF-β-induced CD4(+)Foxp3(+) Regulatory Cells. Int J Biomed Sci. 2013; 4(1):52-7. PMC: 3614670. View

12.

Glass C, Rosenfeld M . The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 2000; 14(2):121-41. View

13.

Chen S, Yang Y, Yan X, Chen J, Yu H, Wang W . Influence of vitamin A status on the antiviral immunity of children with hand, foot and mouth disease. Clin Nutr. 2011; 31(4):543-8. DOI: 10.1016/j.clnu.2011.12.005. View

14.

Schreck R, Rieber P, Baeuerle P . Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J. 1991; 10(8):2247-58. PMC: 452914. DOI: 10.1002/j.1460-2075.1991.tb07761.x. View

15.

Duriancik D, Hoag K . Vitamin A deficiency alters splenic dendritic cell subsets and increases CD8(+)Gr-1(+) memory T lymphocytes in C57BL/6J mice. Cell Immunol. 2010; 265(2):156-63. PMC: 2966341. DOI: 10.1016/j.cellimm.2010.08.006. View

16.

Hu N, Li Q, Zou S . [Effect of vitamin A as an adjuvant therapy for pneumonia in children: a Meta analysis]. Zhongguo Dang Dai Er Ke Za Zhi. 2018; 20(2):146-153. PMC: 7389232. View

17.

Buonocore S, Ahern P, Uhlig H, Ivanov I, Littman D, Maloy K . Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature. 2010; 464(7293):1371-5. PMC: 3796764. DOI: 10.1038/nature08949. View

18.

Zeba A, Sorgho H, Rouamba N, Zongo I, Rouamba J, Guiguemde R . Major reduction of malaria morbidity with combined vitamin A and zinc supplementation in young children in Burkina Faso: a randomized double blind trial. Nutr J. 2008; 7:7. PMC: 2254644. DOI: 10.1186/1475-2891-7-7. View

19.

Nikawa T, Odahara K, Koizumi H, Kido Y, Teshima S, Rokutan K . Vitamin A prevents the decline in immunoglobulin A and Th2 cytokine levels in small intestinal mucosa of protein-malnourished mice. J Nutr. 1999; 129(5):934-41. DOI: 10.1093/jn/129.5.934. View

20.

Klebanoff C, Spencer S, Torabi-Parizi P, Grainger J, Roychoudhuri R, Ji Y . Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells. J Exp Med. 2013; 210(10):1961-76. PMC: 3782040. DOI: 10.1084/jem.20122508. View