Pathophysiology and Inhibition of IL-23 Signaling in Psoriatic Arthritis: A Molecular Insight

Overview

Journal Clin Immunol

Specialty Allergy & Immunology

Date 2018 Sep 10

PMID 30196070

Citations 13

Authors

Cuong Thach Nguyen

Yehudi Bloch

Katarzyna Skladanowska

Savvas N Savvides

Iannis E Adamopoulos

Affiliations

Soon will be listed here.

Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis of unknown etiology, and currently the cellular and molecular interactions that dictate its pathogenesis remain elusive. A role of the interleukin-23 (IL-23)/IL-23R (IL-23 receptor) interaction in the development of psoriasis and PsA is well established. As IL-23 regulates the differentiation and activation of innate and adaptive immunity, it pertains to a very complex pathophysiology involving a plethora of effectors and transducers. In this review, we will discuss recent advances on the cellular and molecular pathophysiological mechanisms that regulate the initiation and progression of PsA as well as new therapeutic approaches for IL-23/IL-23R targeted therapeutics.

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