DNA Double-strand Breaks As Drivers of Neural Genomic Change, Function, and Disease

Overview

Journal DNA Repair (Amst)

Publisher Elsevier

Specialties Biochemistry
Molecular Biology

Date 2018 Sep 10

PMID 30195640

Citations 53

Authors

Frederick W Alt

Bjoern Schwer

Affiliations

Soon will be listed here.

Abstract

Early work from about two decades ago implicated DNA double-strand break (DSB) formation and repair in neuronal development. Findings emerging from recent studies of DSBs in proliferating neural progenitors and in mature, non-dividing neurons suggest important roles of DSBs in brain physiology, aging, cancer, psychiatric and neurodegenerative disorders. We provide an overview of some findings and speculate on what may lie ahead.

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