Effects of Systemic Simvastatin on the Concentrations of Visfatin, Tumor Necrosis Factor-, and Interleukin-6 in Gingival Crevicular Fluid in Patients with Type 2 Diabetes and Chronic Periodontitis

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2018 Sep 7

PMID 30186882

Citations 11

Authors

Maha A Bahammam

Mai S Attia

Affiliations

Soon will be listed here.

Abstract

Purpose: The objective of this study is to explore the relationship between the levels of interleukin- (IL-) 6, tumor necrosis factor- (TNF-) , and visfatin and simvastatin usage, in the gingival crevicular fluids (GCFs) of diabetic patients afflicted with chronic periodontitis.

Methods: Eighty outpatients at the Periodontology Department, Faculty of Dentistry, University Dental Hospital (King Abdulaziz University), were categorized into 4 groups (20 patients per group), on the basis of radiological evaluation of bone loss, clinical attachment levels (CAL), probing depth (PD), and gingival indices: group 1 (healthy periodontium), group 2 (chronic periodontitis + type 2 diabetes), group 3 (chronic periodontitis), and group 4 (type 2 diabetes + chronic periodontitis + simvastatin). Enzyme-linked immunosorbent assays were used to measure IL-6, TNF-, and visfatin levels.

Results: Significantly elevated levels of IL-6, TNF-, and visfatin were seen in group 2 in comparison to groups 1 and 3. Reduced levels were seen in group 4 due to simvastatin usage. Positive association was seen between periodontal variables and the levels of IL-6, TNF-, and visfatin.

Conclusion: Periodontal destruction and diabetes have a synergistic effect on the elevation of inflammatory cytokine levels. Simvastatin may be beneficial in improving periodontal health among diabetic patients.

Citing Articles

Association between visfatin and periodontitis: a systematic review and meta-analysis.

Li Y, Xin C, Xie J, Sun X PeerJ. 2024; 12:e17187.

PMID: 38560458 PMC: 10981885. DOI: 10.7717/peerj.17187.

The Role of Interleukin 6 in Periodontitis and Its Complications.

Mazurek-Mochol M, Bonsmann T, Mochol M, Poniewierska-Baran A, Pawlik A Int J Mol Sci. 2024; 25(4).

PMID: 38396821 PMC: 10889213. DOI: 10.3390/ijms25042146.

Endogenous and microbial biomarkers for periodontitis and type 2 diabetes mellitus.

Li S, Li H, Kong H, Wu S, Cheng C, Xu J Front Endocrinol (Lausanne). 2023; 14:1292596.

PMID: 38149100 PMC: 10750125. DOI: 10.3389/fendo.2023.1292596.

Periodontal disease and visfatin level: A systematic review and meta-analysis.

Bayani M, Heidari M, Almasi-Hashiani A PLoS One. 2023; 18(11):e0293368.

PMID: 37934738 PMC: 10629655. DOI: 10.1371/journal.pone.0293368.

Periodontitis is associated with the increased levels of visfatin: a meta-analysis.

Zhu J, Zhang S, Shi J, Ning N, Wei Y, Zhang Y BMC Oral Health. 2023; 23(1):799.

PMID: 37884949 PMC: 10601249. DOI: 10.1186/s12903-023-03384-2.

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