Association Between Periodontal Health Status and Cognitive Abilities. The Role of Cytokine Profile and Systemic Inflammation

Overview

Journal Curr Alzheimer Res

Publisher Bentham Science Publishers

Specialty Neurology

Date 2017 Mar 21

PMID 28317488

Citations 25

Authors

Marta Sochocka

Maciej Sobczynski

Aleksandra Sender-Janeczek

Katarzyna Zwolinska

Olga Blachowicz

Tomasz Tomczyk

Marek Zietek

Jerzy Leszek

Affiliations

Soon will be listed here.

Abstract

Background: Contemporary neurobiology, periodontal medicine, and immunology are now focusing on the relationship between chronic periodontitis and systemic diseases, which also include Alzheimer's disease (AD). However a causative relationship between dementia and periodontitis has yet to be confirmed.

Objective: The aim of the study was to determine whether periodontal health status and cognitive abilities are correlated with the relative changes in systemic measures of pro- and anti-inflammatory cytokines as a reflection of systemic inflammation. We hypothesized that poor periodontal health status may be associated with cognitive impairment and dementia via the exacerbation of systemic inflammation.

Methods: Based on the periodontal and psychiatric examinations and the cytokine levels produced by unstimulated and LPS-stimulated PBL isolated from 128 participants, we have examined if the coexisting of these two clinically described conditions may have influence on the systemic inflammation. Mini- Mental State Examination (MMSE) and Bleeding on Probing (BoP) test results were combined into the one mathematical function U, which determines the severity of specific condition, called Cognitive and periodontal impairment state. Similarly, the levels of cytokines were combined into the one mathematical function V, whose value determines the level of Inflammatory state. The correlation between U and V was determined.

Results: These results confirm that the presence of cognitive decline and the additional source of proinflammatory mediators, like periodontal health problems, aggravate the systemic inflammation.

Conclusion: It is most likely that the comorbidity of these two disorders may deepen the cognitive impairment, and neurodegenerative lesions and advance to dementia and AD.

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References

Heneka M, Golenbock D, Latz E . Innate immunity in Alzheimer's disease. Nat Immunol. 2015; 16(3):229-36. DOI: 10.1038/ni.3102. View

Heneka M, Carson M, El Khoury J, Landreth G, Brosseron F, Feinstein D . Neuroinflammation in Alzheimer's disease. Lancet Neurol. 2015; 14(4):388-405. PMC: 5909703. DOI: 10.1016/S1474-4422(15)70016-5. View

Sochocka M, Koutsouraki E, Gasiorowski K, Leszek J . Vascular oxidative stress and mitochondrial failure in the pathobiology of Alzheimer's disease: a new approach to therapy. CNS Neurol Disord Drug Targets. 2013; 12(6):870-81. DOI: 10.2174/18715273113129990072. View

Farhad S, Amini S, Khalilian A, Barekatain M, Mafi M, Barekatain M . The effect of chronic periodontitis on serum levels of tumor necrosis factor-alpha in Alzheimer disease. Dent Res J (Isfahan). 2014; 11(5):549-52. PMC: 4241606. View

Trindade S, Olczak T, Gomes-Filho I, Moura-Costa L, Cerqueira E, Galdino-Neto M . Induction of interleukin (IL)-1β, IL-10, IL-8 and immunoglobulin G by Porphyromonas gingivalis HmuY in humans. J Periodontal Res. 2011; 47(1):27-32. DOI: 10.1111/j.1600-0765.2011.01401.x. View

Da Mesquita S, Ferreira A, Sousa J, Correia-Neves M, Sousa N, Marques F . Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system. Neurosci Biobehav Rev. 2016; 68:547-562. DOI: 10.1016/j.neubiorev.2016.06.014. View

Stewart R, Weyant R, Garcia M, Harris T, Launer L, Satterfield S . Adverse oral health and cognitive decline: the health, aging and body composition study. J Am Geriatr Soc. 2013; 61(2):177-84. PMC: 3578234. DOI: 10.1111/jgs.12094. View

Ide M, Harris M, Stevens A, Sussams R, Hopkins V, Culliford D . Periodontitis and Cognitive Decline in Alzheimer's Disease. PLoS One. 2016; 11(3):e0151081. PMC: 4786266. DOI: 10.1371/journal.pone.0151081. View

Gil-Montoya J, Sanchez-Lara I, Carnero-Pardo C, Fornieles F, Montes J, Vilchez R . Is periodontitis a risk factor for cognitive impairment and dementia? A case-control study. J Periodontol. 2014; 86(2):244-53. DOI: 10.1902/jop.2014.140340. View

10.

Lim S, Rodriguez-Ortiz C, Kitazawa M . Infection, systemic inflammation, and Alzheimer's disease. Microbes Infect. 2015; 17(8):549-56. DOI: 10.1016/j.micinf.2015.04.004. View

11.

Sochocka M, Zaczynska E, Tabol A, Czarny A, Leszek J, Sobczynski M . The influence of donepezil and EGb 761 on the innate immunity of human leukocytes: effect on the NF-κB system. Int Immunopharmacol. 2010; 10(12):1505-13. DOI: 10.1016/j.intimp.2010.08.024. View

12.

Syrjala A, Ylostalo P, Ruoppi P, Komulainen K, Hartikainen S, Sulkava R . Dementia and oral health among subjects aged 75 years or older. Gerodontology. 2010; 29(1):36-42. DOI: 10.1111/j.1741-2358.2010.00396.x. View

13.

Poole S, Singhrao S, Kesavalu L, Curtis M, Crean S . Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer's disease brain tissue. J Alzheimers Dis. 2013; 36(4):665-77. DOI: 10.3233/JAD-121918. View

14.

Menegat J, Lira-Junior R, Siqueira M, Brito F, Carvalho A, Fischer R . Cytokine expression in gingival and intestinal tissues of patients with periodontitis and inflammatory bowel disease: An exploratory study. Arch Oral Biol. 2016; 66:141-6. DOI: 10.1016/j.archoralbio.2016.02.018. View

15.

Hajishengallis G . Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol. 2014; 15(1):30-44. PMC: 4276050. DOI: 10.1038/nri3785. View

16.

Kamer A, Craig R, Dasanayake A, Brys M, Glodzik-Sobanska L, de Leon M . Inflammation and Alzheimer's disease: possible role of periodontal diseases. Alzheimers Dement. 2008; 4(4):242-50. DOI: 10.1016/j.jalz.2007.08.004. View

17.

Reis C, Viana da Costa A, Guimaraes J, Tuna D, Braga A, Pacheco J . Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6. Exp Ther Med. 2014; 8(1):323-327. PMC: 4061202. DOI: 10.3892/etm.2014.1724. View

18.

Kamer A, Craig R, Pirraglia E, Dasanayake A, Norman R, Boylan R . TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects. J Neuroimmunol. 2009; 216(1-2):92-7. PMC: 2783848. DOI: 10.1016/j.jneuroim.2009.08.013. View

19.

Page R, Eke P . Case definitions for use in population-based surveillance of periodontitis. J Periodontol. 2007; 78(7 Suppl):1387-99. DOI: 10.1902/jop.2007.060264. View

20.

Abbayya K, Puthanakar N, Naduwinmani S, Chidambar Y . Association between Periodontitis and Alzheimer's Disease. N Am J Med Sci. 2015; 7(6):241-6. PMC: 4488989. DOI: 10.4103/1947-2714.159325. View