Carbon Monoxide Releasing Molecule-2 Protects Mice Against Acute Kidney Injury Through Inhibition of ER Stress

Overview

Journal Korean J Physiol Pharmacol

Specialty Pharmacology

Date 2018 Sep 6

PMID 30181703

Citations 17

Authors

Md Jamal Uddin

Eun Seon Pak

Hunjoo Ha

Affiliations

Soon will be listed here.

Abstract

Acute kidney injury (AKI), which is defined as a rapid decline of renal function, becomes common and recently recognized to be closely intertwined with chronic kidney diseases. Current treatment for AKI is largely supportive, and endoplasmic reticulum (ER) stress has emerged as a novel mediator of AKI. Since carbon monoxide attenuates ER stress, the objective of the present study aimed to determine the protective effect of carbon monoxide releasing molecule-2 (CORM2) on AKI associated with ER stress. Kidney injury was induced after LPS (15 mg/kg) treatment at 12 to 24 h in C57BL/6J mice. Pretreatment of CORM2 (30 mg/kg) effectively prevented LPS-induced oxidative stress and inflammation during AKI in mice. CORM2 treatment also effectively inhibited LPS-induced ER stress in AKI mice. In order to confirm effect of CO on the pathophysiological role of tubular epithelial cells in AKI, we used mProx24 cells. Pretreatment of CORM2 attenuated LPS-induced ER stress, oxidative stress, and inflammation in mProx24 cells. These data suggest that CO therapy may prevent ER stress-mediated AKI.

Citing Articles

Acute kidney injury: exploring endoplasmic reticulum stress-mediated cell death.

Cheng C, Yuan Y, Yuan F, Li X Front Pharmacol. 2024; 15:1308733.

PMID: 38434710 PMC: 10905268. DOI: 10.3389/fphar.2024.1308733.

The effects of CORM3 or NaHS on the oxidative stress caused by chronic kidney disease in rats: potential interaction between CO and HS signaling pathway.

Hamidizad Z, Kadkhodaee M, Kianian F, Ranjbaran M, Seifi B Metab Brain Dis. 2023; 38(8):2653-2664.

PMID: 37695421 DOI: 10.1007/s11011-023-01264-w.

Renoprotective potentials of small molecule natural products targeting mitochondrial dysfunction.

Rahman M, Akter S, Dorotea D, Mazumder A, Uddin M, Hannan M Front Pharmacol. 2022; 13:925993.

PMID: 35910356 PMC: 9334908. DOI: 10.3389/fphar.2022.925993.

Potentials of ketogenic diet against chronic kidney diseases: pharmacological insights and therapeutic prospects.

Kundu S, Hossain K, Moni A, Zahan M, Rahman M, Uddin M Mol Biol Rep. 2022; 49(10):9749-9758.

PMID: 35441940 DOI: 10.1007/s11033-022-07460-8.

Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives.

Akter S, Moni A, Faisal G, Uddin M, Jahan N, Hannan M Int J Environ Res Public Health. 2022; 19(3).

PMID: 35162887 PMC: 8834953. DOI: 10.3390/ijerph19031864.

References

Zhang H, Zhang W, Jiao F, Li X, Zhang H, Wang L . The Nephroprotective Effect of MS-275 on Lipopolysaccharide (LPS)-Induced Acute Kidney Injury by Inhibiting Reactive Oxygen Species (ROS)-Oxidative Stress and Endoplasmic Reticulum Stress. Med Sci Monit. 2018; 24:2620-2630. PMC: 5944402. DOI: 10.12659/MSM.906362. View

Lin H, Liu X, Yu J, Hua F, Hu Z . Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse. PLoS One. 2013; 8(10):e74130. PMC: 3788783. DOI: 10.1371/journal.pone.0074130. View

Kim K, Pae H, Zheng M, Park R, Kim Y, Chung H . Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress. Circ Res. 2007; 101(9):919-27. DOI: 10.1161/CIRCRESAHA.107.154781. View

Xu Y, Guo M, Jiang W, Dong H, Han Y, An X . Endoplasmic reticulum stress and its effects on renal tubular cells apoptosis in ischemic acute kidney injury. Ren Fail. 2016; 38(5):831-7. DOI: 10.3109/0886022X.2016.1160724. View

Park J, Ha H . Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice. Korean J Physiol Pharmacol. 2015; 19(3):269-74. PMC: 4422968. DOI: 10.4196/kjpp.2015.19.3.269. View

Kim H, Jeong J, Kim S, Park S, Chae H, Lee Y . Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-κB/HIF-1α signaling pathway. Sci Rep. 2013; 3:1142. PMC: 3556596. DOI: 10.1038/srep01142. View

Gao X, Fu L, Xiao M, Xu C, Sun L, Zhang T . The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress. Basic Clin Pharmacol Toxicol. 2012; 111(1):14-23. DOI: 10.1111/j.1742-7843.2011.00854.x. View

Ha H, Yu M, Kim K . Melatonin and taurine reduce early glomerulopathy in diabetic rats. Free Radic Biol Med. 1999; 26(7-8):944-50. DOI: 10.1016/s0891-5849(98)00276-7. View

Uchino S, Kellum J, Bellomo R, Doig G, Morimatsu H, Morgera S . Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005; 294(7):813-8. DOI: 10.1001/jama.294.7.813. View

10.

Kim D, Song L, Wang J, Wu H, Gou W, Cui W . Carbon Monoxide Inhibits Islet Apoptosis via Induction of Autophagy. Antioxid Redox Signal. 2017; 28(14):1309-1322. PMC: 5905947. DOI: 10.1089/ars.2016.6979. View

11.

Maeshima A, Takahashi S, Nakasatomi M, Nojima Y . Diverse Cell Populations Involved in Regeneration of Renal Tubular Epithelium following Acute Kidney Injury. Stem Cells Int. 2015; 2015:964849. PMC: 4452180. DOI: 10.1155/2015/964849. View

12.

Li X, Hassoun H, Santora R, Rabb H . Organ crosstalk: the role of the kidney. Curr Opin Crit Care. 2009; 15(6):481-7. DOI: 10.1097/MCC.0b013e328332f69e. View

13.

Otterbein L, Mantell L, Choi A . Carbon monoxide provides protection against hyperoxic lung injury. Am J Physiol. 1999; 276(4):L688-94. DOI: 10.1152/ajplung.1999.276.4.L688. View

14.

Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding H . Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science. 2000; 287(5453):664-6. DOI: 10.1126/science.287.5453.664. View

15.

Rushworth S, Chen X, Mackman N, Ogborne R, OConnell M . Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. J Immunol. 2005; 175(7):4408-15. DOI: 10.4049/jimmunol.175.7.4408. View

16.

Linkermann A, Chen G, Dong G, Kunzendorf U, Krautwald S, Dong Z . Regulated cell death in AKI. J Am Soc Nephrol. 2014; 25(12):2689-701. PMC: 4243360. DOI: 10.1681/ASN.2014030262. View

17.

Kim S, Joe Y, Kim H, Kim Y, Jeong S, Pae H . Endoplasmic reticulum stress-induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 to regulate inflammatory cytokine production. J Immunol. 2015; 194(9):4498-506. PMC: 4400814. DOI: 10.4049/jimmunol.1401399. View

18.

Wang Q, Wang H, Jia Y, Pan H, Ding H . Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma. Cancer Chemother Pharmacol. 2017; 79(5):1031-1041. DOI: 10.1007/s00280-017-3299-4. View

19.

Sohn M, Kim K, Uddin M, Lee G, Hwang I, Kang H . Delayed treatment with fenofibrate protects against high-fat diet-induced kidney injury in mice: the possible role of AMPK autophagy. Am J Physiol Renal Physiol. 2016; 312(2):F323-F334. DOI: 10.1152/ajprenal.00596.2015. View

20.

Agarwal A, Nick H . Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expression. J Am Soc Nephrol. 2000; 11(5):965-973. DOI: 10.1681/ASN.V115965. View