Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Feb 15

PMID 35162887

Authors

Sumaya Akter

Akhi Moni

Golam Mahbub Faisal

Muhammad Ramiz Uddin

Nourin Jahan

Md Abdul Hannan

Asadur Rahman

Md Jamal Uddin

Affiliations

Soon will be listed here.

Abstract

Both acute and chronic kidney diseases substantially contribute to the morbidities and mortality of patients worldwide. The existing therapeutics, which are mostly developed from synthetic sources, present some unexpected effects in patients, provoking researchers to explore potential novel alternatives. Natural products that have protective effects against various renal pathologies could be potential drug candidates for kidney diseases. Mangiferin is a natural polyphenol predominantly isolated from and possesses multiple health benefits against various human ailments, including kidney disease. The main objective of this review is to update the renoprotective potentials of mangiferin with underlying molecular pharmacology and to highlight the recent development of mangiferin-based therapeutics toward kidney problems. Literature published over the past decade suggests that treatment with mangiferin attenuates renal inflammation and oxidative stress, improves interstitial fibrosis and renal dysfunction, and ameliorates structural alteration in the kidney. Therefore, mangiferin could be used as a multi-target therapeutic candidate to treat renal diseases. Although mangiferin-loaded nanoparticles have shown therapeutic promise against various human diseases, there is limited information on the targeted delivery of mangiferin in the kidney. Further research is required to gain insight into the molecular pharmacology of mangiferin targeting kidney diseases and translate the preclinical results into clinical use.

Citing Articles

Mangiferin: An effective agent against human malignancies.

Irshad N, Naeem H, Shahbaz M, Imran M, Mujtaba A, Hussain M Food Sci Nutr. 2024; 12(10):7137-7157.

PMID: 39479608 PMC: 11521646. DOI: 10.1002/fsn3.4434.

Ceibinin, a new positional isomer of mangiferin from the inflorescence of (Bombacaceae), elicits similar antioxidant effect but no anti-inflammatory potential compared to mangiferin.

Taiwo B, Miller A, Fielding A, Sarker S, van Heerden F, Fatokun A Heliyon. 2024; 10(1):e23335.

PMID: 38332887 PMC: 10851220. DOI: 10.1016/j.heliyon.2023.e23335.

Ferroptosis: a new strategy for Chinese herbal medicine treatment of diabetic nephropathy.

Wei M, Liu X, Tan Z, Tian X, Li M, Wei J Front Endocrinol (Lausanne). 2023; 14:1188003.

PMID: 37361521 PMC: 10289168. DOI: 10.3389/fendo.2023.1188003.

Phospholipid-Based Topical Nano-Hydrogel of Mangiferin: Enhanced Topical Delivery and Improved Dermatokinetics.

Alkholifi F, Alam A, Foudah A, Yusufoglu H Gels. 2023; 9(3).

PMID: 36975627 PMC: 10048531. DOI: 10.3390/gels9030178.

An In-Silico Identification of Potential Flavonoids against Kidney Fibrosis Targeting TGFβR-1.

Rahman M, Biswas P, Dey D, Hannan M, Sahabuddin M, Araf Y Life (Basel). 2022; 12(11).

PMID: 36362919 PMC: 9694304. DOI: 10.3390/life12111764.

References

Kao M, Ang D, Pall A, Struthers A . Oxidative stress in renal dysfunction: mechanisms, clinical sequelae and therapeutic options. J Hum Hypertens. 2009; 24(1):1-8. DOI: 10.1038/jhh.2009.70. View

Xu G, Sun C, Qin X, Han Y, Li Y, Xie G . Effects of ethanol extract of Bombax ceiba leaves and its main constituent mangiferin on diabetic nephropathy in mice. Chin J Nat Med. 2017; 15(8):597-605. DOI: 10.1016/S1875-5364(17)30087-0. View

Ehianeta T, Laval S, Yu B . Bio- and chemical syntheses of mangiferin and congeners. Biofactors. 2016; 42(5):445-458. DOI: 10.1002/biof.1279. View

Wang X, Gao L, Lin H, Song J, Wang J, Yin Y . Mangiferin prevents diabetic nephropathy progression and protects podocyte function via autophagy in diabetic rat glomeruli. Eur J Pharmacol. 2018; 824:170-178. DOI: 10.1016/j.ejphar.2018.02.009. View

Uddin M, Kim E, Hannan M, Ha H . Pharmacotherapy against Oxidative Stress in Chronic Kidney Disease: Promising Small Molecule Natural Products Targeting Nrf2-HO-1 Signaling. Antioxidants (Basel). 2021; 10(2). PMC: 7915495. DOI: 10.3390/antiox10020258. View

Yang H, Gao L, Niu Y, Zhou Y, Lin H, Jiang J . Mangiferin Inhibits Renal Urate Reabsorption by Modulating Urate Transporters in Experimental Hyperuricemia. Biol Pharm Bull. 2015; 38(10):1591-8. DOI: 10.1248/bpb.b15-00402. View

Demeyer S, Athipornchai A, Pabunrueang P, Trakulsujaritchok T . Development of mangiferin loaded chitosan-silica hybrid scaffolds: Physicochemical and bioactivity characterization. Carbohydr Polym. 2021; 261:117905. DOI: 10.1016/j.carbpol.2021.117905. View

Bhattacharyya S, Ahmmed S, Saha B, Mukherjee P . Soya phospholipid complex of mangiferin enhances its hepatoprotectivity by improving its bioavailability and pharmacokinetics. J Sci Food Agric. 2013; 94(7):1380-8. DOI: 10.1002/jsfa.6422. View

Liu Y, Zhu X, Zhang L, Lu Q, Wang J, Zhang F . Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2013; 721(1-3):355-64. DOI: 10.1016/j.ejphar.2013.08.029. View

10.

Luo F, Lv Q, Zhao Y, Hu G, Huang G, Zhang J . Quantification and purification of mangiferin from Chinese Mango (Mangifera indica L.) cultivars and its protective effect on human umbilical vein endothelial cells under H(2)O(2)-induced stress. Int J Mol Sci. 2012; 13(9):11260-11274. PMC: 3472743. DOI: 10.3390/ijms130911260. View

11.

He L, Peng X, Zhu J, Chen X, Liu H, Tang C . Mangiferin attenuate sepsis-induced acute kidney injury via antioxidant and anti-inflammatory effects. Am J Nephrol. 2014; 40(5):441-50. DOI: 10.1159/000369220. View

12.

Chavan J, Kshirsagar P, Jadhav S, Nalavade V, Gurme S, Pai S . Elicitor-mediated enhancement of biomass, polyphenols, mangiferin production and antioxidant activities in callus cultures of L. 3 Biotech. 2021; 11(6):285. PMC: 8140032. DOI: 10.1007/s13205-021-02836-2. View

13.

Ghosh M, Das J, Sil P . D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-κB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin. Free Radic Res. 2011; 46(2):116-32. DOI: 10.3109/10715762.2011.644240. View

14.

Uddin M, Jeong J, Pak E, Ha H . CO-Releasing Molecule-2 Prevents Acute Kidney Injury through Suppression of ROS-Fyn-ER Stress Signaling in Mouse Model. Oxid Med Cell Longev. 2021; 2021:9947772. PMC: 8277502. DOI: 10.1155/2021/9947772. View

15.

Jyotshna , Khare P, Shanker K . Mangiferin: A review of sources and interventions for biological activities. Biofactors. 2016; 42(5):504-514. DOI: 10.1002/biof.1308. View

16.

Zou T, Wu H, Li H, Jia Q, Song G . Comparison of microwave-assisted and conventional extraction of mangiferin from mango (Mangifera indica L.) leaves. J Sep Sci. 2013; 36(20):3457-62. DOI: 10.1002/jssc.201300518. View

17.

Patra N, Dehury N, Pal A, Behera A, Patra S . Preparation and mechanistic aspect of natural xanthone functionalized gold nanoparticle. Mater Sci Eng C Mater Biol Appl. 2018; 90:439-445. DOI: 10.1016/j.msec.2018.04.091. View

18.

. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388(10053):1603-1658. PMC: 5388857. DOI: 10.1016/S0140-6736(16)31460-X. View

19.

Li X, Yan Z, Carlstrom M, Tian J, Zhang X, Zhang W . Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion. Front Pharmacol. 2020; 11:49. PMC: 7020245. DOI: 10.3389/fphar.2020.00049. View

20.

Matkowski A, Kus P, Goralska E, Wozniak D . Mangiferin - a bioactive xanthonoid, not only from mango and not just antioxidant. Mini Rev Med Chem. 2012; 13(3):439-55. View