Cumulative Evidence for Relationships Between Multiple Variants in 8q24 and Colorectal Cancer Incidence

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2018 Sep 2

PMID 30170403

Citations 2

Authors

Yu Tong

Huiqing Wang

Shiping Li

Fengyan Zhao

Junjie Ying

Yi Qu

Dezhi Mu

Affiliations

Soon will be listed here.

Abstract

Genome-wide association studies (GWAS) have identified multiple independent cancer susceptibility loci at chromosome 8q24.We conducted a comprehensive research synopsis and meta-analysis to evaluate associations between 6 variants in 8q24 and risk of colorectal cancer using data from 31 eligible articles totaling 41,942 cases and 49,968 controls.Of the 6 variants located in 8q24, 3 were significantly associated with risk of colorectal cancer. In particular, both homozygous TT and heterozygous CT genotypes of rs10505477, as well as the GG and TG genotypes of rs6983267, were associated with risk of colorectal cancer.Our study provides summary evidence that common variants in the 8q24 are associated with risk of colorectal cancer in this large-scale research synopsis and meta-analysis. Further studies are needed to explore the exact role of the variants in the 8q24 involved in the etiology of colorectal cancer.

Citing Articles

Long non-coding RNA polymorphisms on 8q24 are associated with the prognosis of gastric cancer in a Chinese population.

Zhang Y, Wu Y, Jia Z, Cao D, Yang N, Wang Y PeerJ. 2020; 8:e8600.

PMID: 32117633 PMC: 7039120. DOI: 10.7717/peerj.8600.

Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis.

Jin K, Wang S, Zhang Y, Xia M, Mo Y, Li X Cell Mol Life Sci. 2019; 76(21):4275-4289.

PMID: 31309249 PMC: 6803569. DOI: 10.1007/s00018-019-03222-1.

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